I17RC_HUMAN » Interleukin-17 receptor C

I17RC_HUMAN » Interleukin-17 receptor C
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I17RC_HUMAN » Interleukin-17 receptor C » IL-17 receptor C; IL-17RC; Interleukin-17 receptor homolog;IL17Rhom; Interleukin-17 receptor-like protein;IL-17RL; ZcytoR14;
Hydrophobic Thickness 28.8 ± 1.8 Å
Tilt Angle 0 ± 1°
ΔGtransfer -41.9 kcal/mol
ΔGfold -24.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 539-564 (533-565)
Pathways none
PDB none
OPM none
Complexes none
Interactions

I17RA, Complex: I17RC:I17RA, PubMed

Domains

AA: 142-530, Interleukin-17 receptor extracellular region

AA: 584-737, PDBID: 4NUX, Subunit A, Seq Identity:23%, SEFIR domain

UniProt annotation for I17RC_HUMAN » Interleukin-17 receptor C
TISSUE SPECIFICITY: Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate. Low expression in thymus and leukocytes. Expressed (at protein level) in prostate and prostate cancer, skeletal muscle, kidney and placenta.

INDUCTION: By HGF and VEGF.

UniProt features for I17RC_HUMAN » Interleukin-17 receptor C
SIGNAL 1 20
CHAIN 21 791 Interleukin-17 receptor C.
DOMAIN 583 735 SEFIR.
Amino Acid Sequence for I17RC_HUMAN » Interleukin-17 receptor C
MPVPWFLLSL ALGRSPVVLS LERLVGPQDA THCSPVSLEP WGDEERLRVQ FLAQQSLSLA PVTAATARTA LSGLSGADGR REERGRGKSW VCLSLGGSGN TEPQKKGLSC RLWDSDILCL PGDIVPAPGP VLAPTHLQTE LVLRCQKETD CDLCLRVAVH LAVHGHWEEP EDEEKFGGAA DSGVEEPRNA SLQAQVVLSF QAYPTARCVL LEVQVPAALV QFGQSVGSVV YDCFEAALGS EVRIWSYTQP RYEKELNHTQ QLPDCRGLEV WNSIPSCWAL PWLNVSADGD NVHLVLNVSE EQHFGLSLYW NQVQGPPKPR WHKNLTGPQI ITLNHTDLVP CLCIQVWPLE PDSVRTNICP FREDPRAHQN LWQAARLQLL TLQSWLLDAP CSLPAEAALC WRAPGGDPCQ PLVPPLSWEN VTVDKVLEFP LLKGHPNLCV QVNSSEKLQL QECLWADSLG PLKDDVLLLE TRGPQDNRSL CALEPSGCTS LPSKASTRAA RLGEYLLQDL QSGQCLQLWD DDLGALWACP MDKYIHKRWA LVWLACLLFA AALSLILLLK KDHAKGWLRL LKQDVRSGAA ARGRAALLLY SADDSGFERL VGALASALCQ LPLRVAVDLW SRRELSAQGP VAWFHAQRRQ TLQEGGVVVL LFSPGAVALC SEWLQDGVSG PGAHGPHDAF RASLSCVLPD FLQGRAPGSY VGACFDRLLH PDAVPALFRT VPVFTLPSQL PDFLGALQQP RAPRSGRLQE RAEQVSRALQ PALDSYFHPP GTPAPGRGVG PGAGPGAGDG T