I17RB_HUMAN » Interleukin-17 receptor B

I17RB_HUMAN » Interleukin-17 receptor B
Magnify I17RB_HUMAN » Interleukin-17 receptor BEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I17RB_HUMAN » Interleukin-17 receptor B » IL-17 receptor B; IL-17RB; Cytokine receptor-like 4;IL-17 receptor homolog 1;IL-17Rh1; IL17Rh1; Interleukin-17B receptor;IL-17B receptor;
Hydrophobic Thickness 36.0 ± 3.0 Å
Tilt Angle 14 ± 1°
ΔGtransfer -26.8 kcal/mol
ΔGfold -19.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 290-315 (290-321)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB none
OPM none
Complexes none
Interactions

I17RA, Complex: IL25:I17RA:I17RB

I17RD, Complex: I17RB:I17RD, PubMed

Domains

AA: 22-175, PDBID: 3JVF, Subunit C, Seq Identity:20%, Interleukin-17 receptor, fibronectin-III-like domain 1

AA: 176-271, PDBID: 3JVF, Subunit C, Seq Identity:26%, Interleukin 17 receptor D

AA: 332-479, PDBID: 3VBC, Subunit A, Seq Identity:80%, SEFIR domain

UniProt annotation for I17RB_HUMAN » Interleukin-17 receptor B
FUNCTION: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

SUBUNIT: Interacts with DAZAP2.

TISSUE SPECIFICITY: Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.

UniProt features for I17RB_HUMAN » Interleukin-17 receptor B
SIGNAL 1 17
CHAIN 18 502 Interleukin-17 receptor B.
DOMAIN 331 477 SEFIR.
Amino Acid Sequence for I17RB_HUMAN » Interleukin-17 receptor B
MSLVLLSLAA LCRSAVPREP TVQCGSETGP SPEWMLQHDL IPGDLRDLRV EPVTTSVATG DYSILMNVSW VLRADASIRL LKATKICVTG KSNFQSYSCV RCNYTEAFQT QTRPSGGKWT FSYIGFPVEL NTVYFIGAHN IPNANMNEDG PSMSVNFTSP GCLDHIMKYK KKCVKAGSLW DPNITACKKN EETVEVNFTT TPLGNRYMAL IQHSTIIGFS QVFEPHQKKQ TRASVVIPVT GDSEGATVQL TPYFPTCGSD CIRHKGTVVL CPQTGVPFPL DNNKSKPGGW LPLLLLSLLV ATWVLVAGIY LMWRHERIKK TSFSTTTLLP PIKVLVVYPS EICFHHTICY FTEFLQNHCR SEVILEKWQK KKIAEMGPVQ WLATQKKAAD KVVFLLSNDV NSVCDGTCGK SEGSPSENSQ DLFPLAFNLF CSDLRSQIHL HKYVVVYFRE IDTKDDYNAL SVCPKYHLMK DATAFCAELL HVKQQVSAGK RSQACHDGCC SL