I17RA_HUMAN » Interleukin-17 receptor A

I17RA_HUMAN » Interleukin-17 receptor A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I17RA_HUMAN » Interleukin-17 receptor A » IL-17 receptor A; IL-17RA; CDw217;
Hydrophobic Thickness 38.8 ± 3.6 Å
Tilt Angle 30 ± 0°
ΔGtransfer -31.4 kcal/mol
ΔGfold -21.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 317-345 (316-348)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB 4nux (376-591), 4hsa (C/F=32-317), 3jvf (C=32-317)
OPM none
Complexes none
Interactions

I17RB, Complex: IL25:I17RA:I17RB

I17RC, Complex: I17RC:I17RA, PubMed

I17RD, Complex: I17RA:I17RD, PubMed

I17RE, Complex: I17RA:I17RE, PubMed

Domains

AA: 48-198, PDBID: 3JVF, Subunit C, Seq Identity:100%, Interleukin-17 receptor, fibronectin-III-like domain 1

AA: 199-303, PDBID: 3JVF, Subunit C, Seq Identity:100%, Interleukin 17 receptor D

AA: 378-536, PDBID: 4NUX, Subunit A, Seq Identity:100%, SEFIR domain

UniProt annotation for I17RA_HUMAN » Interleukin-17 receptor A
FUNCTION: Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.

SUBUNIT: Forms heterodimers with IL17RE; the heterodimer binds IL17C.

TISSUE SPECIFICITY: Widely expressed.

DISEASE: Candidiasis, familial, 5 (CANDF5) OMIM: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. mutations affecting the gene represented in this entry.

UniProt features for I17RA_HUMAN » Interleukin-17 receptor A
SIGNAL 1 32
CHAIN 33 866 Interleukin-17 receptor A.
DOMAIN 377 534 SEFIR.
DISULFID 43 50
DISULFID 57 126
DISULFID 185 196
DISULFID 245 276
DISULFID 290 294
Amino Acid Sequence for I17RA_HUMAN » Interleukin-17 receptor A
MGAARSPPSA VPGPLLGLLL LLLGVLAPGG ASLRLLDHRA LVCSQPGLNC TVKNSTCLDD SWIHPRNLTP SSPKDLQIQL HFAHTQQGDL FPVAHIEWTL QTDASILYLE GAELSVLQLN TNERLCVRFE FLSKLRHHHR RWRFTFSHFV VDPDQEYEVT VHHLPKPIPD GDPNHQSKNF LVPDCEHARM KVTTPCMSSG SLWDPNITVE TLEAHQLRVS FTLWNESTHY QILLTSFPHM ENHSCFEHMH HIPAPRPEEF HQRSNVTLTL RNLKGCCRHQ VQIQPFFSSC LNDCLRHSAT VSCPEMPDTP EPIPDYMPLW VYWFITGISI LLVGSVILLI VCMTWRLAGP GSEKYSDDTK YTDGLPAADL IPPPLKPRKV WIIYSADHPL YVDVVLKFAQ FLLTACGTEV ALDLLEEQAI SEAGVMTWVG RQKQEMVESN SKIIVLCSRG TRAKWQALLG RGAPVRLRCD HGKPVGDLFT AAMNMILPDF KRPACFGTYV VCYFSEVSCD GDVPDLFGAA PRYPLMDRFE EVYFRIQDLE MFQPGRMHRV GELSGDNYLR SPGGRQLRAA LDRFRDWQVR CPDWFECENL YSADDQDAPS LDEEVFEEPL LPPGTGIVKR APLVREPGSQ ACLAIDPLVG EEGGAAVAKL EPHLQPRGQP APQPLHTLVL AAEEGALVAA VEPGPLADGA AVRLALAGEG EACPLLGSPG AGRNSVLFLP VDPEDSPLGS STPMASPDLL PEDVREHLEG LMLSLFEQSL SCQAQGGCSR PAMVLTDPHT PYEEEQRQSV QSDQGYISRS SPQPPEGLTE MEEEEEEEQD PGKPALPLSP EDLESLRSLQ RQLLFRQLQK NSGWDTMGSE SEGPSA