I15RA_HUMAN » Interleukin-15 receptor subunit alpha

I15RA_HUMAN » Interleukin-15 receptor subunit alpha
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
I15RA_HUMAN » Interleukin-15 receptor subunit alpha » IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA;
Hydrophobic Thickness 36.0 ± 2.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -36.7 kcal/mol
ΔGfold -10.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 208-229 (202-231)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

HTLV-I infection (KEGG)

Intestinal immune network for IgA production (KEGG)

Jak-STAT signaling pathway (KEGG)

PDB 2ers (31-96), 2z3r (B/D...=31-132), 2z3q (B/D=31-132), 4gs7 (D=30-97)
OPM none
Complexes

IL2RB:IL2RG:IL15:I15RA_HUMAN

Interactions

IL2RB, Complex: IL2RB:IL2RG:IL15:I15RA, PDBID: 4gs7, PubMed

IL2RG, Complex: I15RA:IL2RG, PubMed

UFO, Complex: UFO:I15RA, PubMed

Domains none
UniProt annotation for I15RA_HUMAN » Interleukin-15 receptor subunit alpha
FUNCTION: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.

SUBUNIT: The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK.

TISSUE SPECIFICITY: Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.

UniProt features for I15RA_HUMAN » Interleukin-15 receptor subunit alpha
SIGNAL 1 30 Potential.
CHAIN 31 267 Interleukin-15 receptor subunit alpha.
CHAIN 31 ? Soluble interleukin-15 receptor subunit alpha.
DOMAIN 31 95 Sushi.
DISULFID 33 75
DISULFID 59 93
Amino Acid Sequence for I15RA_HUMAN » Interleukin-15 receptor subunit alpha
MAPRRARGCR TLGLPALLLL LLLRPPATRG ITCPPPMSVE HADIWVKSYS LYSRERYICN SGFKRKAGTS SLTECVLNKA TNVAHWTTPS LKCIRDPALV HQRPAPPSTV TTAGVTPQPE SLSPSGKEPA ASSPSSNNTA ATTAAIVPGS QLMPSKSPST GTTEISSHES SHGTPSQTTA KNWELTASAS HQPPGVYPQG HSDTTVAIST STVLLCGLSA VSLLACYLKS RQTPPLASVE MEAMEALPVT WGTSSRDEDL ENCSHHL