I13R2_HUMAN » Interleukin-13 receptor subunit alpha-2

I13R2_HUMAN » Interleukin-13 receptor subunit alpha-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I13R2_HUMAN » Interleukin-13 receptor subunit alpha-2 » IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2; Interleukin-13-binding protein;
Hydrophobic Thickness 29.6 ± 2.0 Å
Tilt Angle 3 ± 0°
ΔGtransfer -46.1 kcal/mol
ΔGfold -20.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 340-363 (334-365)
Pathways

Jak-STAT signaling pathway (KEGG)

PDB 3lb6 (C/D=1-380)
OPM none
Complexes none
Interactions

ERBB2, Complex: I13R2:ERBB2, PubMed

IGF1R, Complex: I13R2:IGF1R, PubMed

NOTC2, Complex: I13R2:NOTC2, PubMed

Domains

AA: 142-235, PDBID: 3LB6, Subunit C, Seq Identity:100%, Interleukin-6 receptor alpha chain, binding

UniProt annotation for I13R2_HUMAN » Interleukin-13 receptor subunit alpha-2
FUNCTION: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

UniProt features for I13R2_HUMAN » Interleukin-13 receptor subunit alpha-2
SIGNAL 1 26 Potential.
CHAIN 27 380 Interleukin-13 receptor subunit alpha-2.
DOMAIN 31 124 Fibronectin type-III 1.
DOMAIN 137 225 Fibronectin type-III 2.
DOMAIN 238 336 Fibronectin type-III 3.
MOTIF 322 326 WSXWS motif.
DISULFID 65 113
DISULFID 145 155
DISULFID 184 197
DISULFID 269 316
Amino Acid Sequence for I13R2_HUMAN » Interleukin-13 receptor subunit alpha-2
MAFVCLAIGC LYTFLISTTF GCTSSSDTEI KVNPPQDFEI VDPGYLGYLY LQWQPPLSLD HFKECTVEYE LKYRNIGSET WKTIITKNLH YKDGFDLNKG IEAKIHTLLP WQCTNGSEVQ SSWAETTYWI SPQGIPETKV QDMDCVYYNW QYLLCSWKPG IGVLLDTNYN LFYWYEGLDH ALQCVDYIKA DGQNIGCRFP YLEASDYKDF YICVNGSSEN KPIRSSYFTF QLQNIVKPLP PVYLTFTRES SCEIKLKWSI PLGPIPARCF DYEIEIREDD TTLVTATVEN ETYTLKTTNE TRQLCFVVRS KVNIYCSDDG IWSEWSDKQC WEGEDLSKKT LLRFWLPFGF ILILVIFVTG LLLRKPNTYP KMIPEFFCDT