I13R1_HUMAN » Interleukin-13 receptor subunit alpha-1

I13R1_HUMAN » Interleukin-13 receptor subunit alpha-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I13R1_HUMAN » Interleukin-13 receptor subunit alpha-1 » IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Cancer/testis antigen 19;CT19;
Hydrophobic Thickness 35.6 ± 1.8 Å
Tilt Angle 1 ± 1°
ΔGtransfer -48.9 kcal/mol
ΔGfold -23.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 343-368 (342-370)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Jak-STAT signaling pathway (KEGG)

PDB 4hwb (A=223-336), 3bpn (C=29-342), 3bpo (C=29-342)
OPM none
Complexes

IL4RA:I13R1:IL13_HUMAN

IL4RA:I13R1:IL4_HUMAN

Interactions

IL2RG, Complex: IL2RG:I13R1, PubMed

IL4RA, Complex: I13R1:IL13:IL4RA, PDBID: 3bpo

Domains

AA: 131-225, PDBID: 3BPN, Subunit C, Seq Identity:100%, Interleukin-6 receptor alpha chain, binding

UniProt annotation for I13R1_HUMAN » Interleukin-13 receptor subunit alpha-1
FUNCTION: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

SUBUNIT: Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1.

TISSUE SPECIFICITY: Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

UniProt features for I13R1_HUMAN » Interleukin-13 receptor subunit alpha-1
SIGNAL 1 21 Potential.
CHAIN 22 427 Interleukin-13 receptor subunit alpha-1.
MOTIF 327 331 WSXWS motif.
MOTIF 374 382 Box 1 motif.
DISULFID 62 102
DISULFID 95 117
DISULFID 134 144
DISULFID 173 185
DISULFID 257 320
DISULFID 282 296
Amino Acid Sequence for I13R1_HUMAN » Interleukin-13 receptor subunit alpha-1
MEWPARLCGL WALLLCAGGG GGGGGAAPTE TQPPVTNLSV SVENLCTVIW TWNPPEGASS NCSLWYFSHF GDKQDKKIAP ETRRSIEVPL NERICLQVGS QCSTNESEKP SILVEKCISP PEGDPESAVT ELQCIWHNLS YMKCSWLPGR NTSPDTNYTL YYWHRSLEKI HQCENIFREG QYFGCSFDLT KVKDSSFEQH SVQIMVKDNA GKIKPSFNIV PLTSRVKPDP PHIKNLSFHN DDLYVQWENP QNFISRCLFY EVEVNNSQTE THNVFYVQEA KCENPEFERN VENTSCFMVP GVLPDTLNTV RIRVKTNKLC YEDDKLWSNW SQEMSIGKKR NSTLYITMLL IVPVIVAGAI IVLLLYLKRL KIIIFPPIPD PGKIFKEMFG DQNDDTLHWK KYDIYEKQTK EETDSVVLIE NLKKASQ