I12R1_HUMAN » Interleukin-12 receptor subunit beta-1

I12R1_HUMAN » Interleukin-12 receptor subunit beta-1
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Topology in Plasma membrane
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cytoplasmic side
I12R1_HUMAN » Interleukin-12 receptor subunit beta-1 » IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; IL-12 receptor beta component;
Hydrophobic Thickness 34.4 ± 3.2 Å
Tilt Angle 18 ± 14°
ΔGtransfer -21.8 kcal/mol
ΔGfold -16.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 545-570 (545-575)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Jak-STAT signaling pathway (KEGG)

PDB none
OPM none
Complexes none
Interactions

I12R2, Complex: I12R2:I12R1, PubMed

IL23R, Complex: IL23R:I12R1, PubMed

Domains

AA: 447-532, PDBID: 1TDQ, Subunit A, Seq Identity:28%, Fibronectin type III domain

UniProt annotation for I12R1_HUMAN » Interleukin-12 receptor subunit beta-1
FUNCTION: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

SUBUNIT: Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

DISEASE: Immunodeficiency 30 (IMD30) OMIM: A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD30 has low penetrance, and affected individuals have relatively mild disease and good prognosis. BCG disease and salmonellosis are the most frequent infections in IMD30 patients. mutations affecting the gene represented in this entry.

UniProt features for I12R1_HUMAN » Interleukin-12 receptor subunit beta-1
SIGNAL 1 23 Potential.
CHAIN 24 662 Interleukin-12 receptor subunit beta-1.
DOMAIN 43 133 Fibronectin type-III 1.
DOMAIN 143 236 Fibronectin type-III 2.
DOMAIN 237 337 Fibronectin type-III 3.
DOMAIN 338 444 Fibronectin type-III 4.
DOMAIN 445 539 Fibronectin type-III 5.
MOTIF 222 226 WSXWS motif.
MOTIF 577 585 Box 1 motif.
DISULFID 52 62 By similarity.
Amino Acid Sequence for I12R1_HUMAN » Interleukin-12 receptor subunit beta-1
MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL RCYRISSDRY ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS DQAGVSVLYT VTLWVESWAR NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP WKLGDCGPQD DDTESCLCPL EMNVAQEFQL RRRQLGSQGS SWSKWSSPVC VPPENPPQPQ VRFSVEQLGQ DGRRRLTLKE QPTQLELPEG CQGLAPGTEV TYRLQLHMLS CPCKAKATRT LHLGKMPYLS GAAYNVAVIS SNQFGPGLNQ TWHIPADTHT EPVALNISVG TNGTTMYWPA RAQSMTYCIE WQPVGQDGGL ATCSLTAPQD PDPAGMATYS WSRESGAMGQ EKCYYITIFA SAHPEKLTLW STVLSTYHFG GNASAAGTPH HVSVKNHSLD SVSVDWAPSL LSTCPGVLKE YVVRCRDEDS KQVSEHPVQP TETQVTLSGL RAGVAYTVQV RADTAWLRGV WSQPQRFSIE VQVSDWLIFF ASLGSFLSIL LVGVLGYLGL NRAARHLCPP LPTPCASSAI EFPGGKETWQ WINPVDFQEE ASLQEALVVE MSWDKGERTE PLEKTELPEG APELALDTEL SLEDGDRCKA KM