I10R2_HUMAN » Interleukin-10 receptor subunit beta

I10R2_HUMAN » Interleukin-10 receptor subunit beta
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I10R2_HUMAN » Interleukin-10 receptor subunit beta » IL-10 receptor subunit beta; IL-10R subunit beta; IL-10RB; Cytokine receptor class-II member 4;Cytokine receptor family 2 member 4;CRF2-4; Interleukin-10 receptor subunit 2;IL-10R subunit 2; IL-10R2;
Hydrophobic Thickness 36.4 ± 4.8 Å
Tilt Angle 34 ± 2°
ΔGtransfer -31.6 kcal/mol
ΔGfold -26.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 221-249 (219-254)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Epstein-Barr virus infection (KEGG)

Jak-STAT signaling pathway (KEGG)

Toxoplasmosis (KEGG)

Tuberculosis (KEGG)

PDB 3lqm (20-220)
OPM none
Complexes none
Interactions

I10R1, Complex: I10R2:I10R1, PubMed

Domains

AA: 1-100, PDBID: 3LQM, Subunit B, Seq Identity:100%, Tissue factor

AA: 111-213, PDBID: 3LQM, Subunit B, Seq Identity:100%, Interferon-alpha/beta receptor, fibronectin type III

UniProt annotation for I10R2_HUMAN » Interleukin-10 receptor subunit beta
FUNCTION: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

SUBUNIT: Heterodimer with IFNLR1.

DISEASE: Inflammatory bowel disease 25 (IBD25) OMIM: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. mutations affecting the gene represented in this entry.

UniProt features for I10R2_HUMAN » Interleukin-10 receptor subunit beta
SIGNAL 1 19
CHAIN 20 325 Interleukin-10 receptor subunit beta.
DOMAIN 113 205 Fibronectin type-III.
DISULFID 66 74
DISULFID 188 209
Amino Acid Sequence for I10R2_HUMAN » Interleukin-10 receptor subunit beta
MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL TFTAQYLSYR IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW VNITFCPVDD TIIGPPGMQV EVLADSLHMR FLAPKIENEY ETWTMKNVYN SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN LEPWTTYCVQ VRGFLPDRNK AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG CFALLWCVYK KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE DSESGKQNPG DSCSLGTPPG QGPQS