I10R1_HUMAN » Interleukin-10 receptor subunit alpha

I10R1_HUMAN » Interleukin-10 receptor subunit alpha
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Topology in Plasma membrane
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cytoplasmic side
I10R1_HUMAN » Interleukin-10 receptor subunit alpha » IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a;Interleukin-10 receptor subunit 1;IL-10R subunit 1; IL-10R1;
Hydrophobic Thickness 33.2 ± 3.6 Å
Tilt Angle 34 ± 2°
ΔGtransfer -30.3 kcal/mol
ΔGfold -24.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 230-255 (227-264)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Epstein-Barr virus infection (KEGG)

Jak-STAT signaling pathway (KEGG)

Toxoplasmosis (KEGG)

Tuberculosis (KEGG)

PDB 1lqs (R/S=22-235), 1j7v (R=22-235), 1y6k (R=22-235), 1y6m (R=22-235), 1y6n (R=22-235)
OPM none
Complexes none
Interactions

I10R2, Complex: I10R2:I10R1, PubMed

Domains

AA: 3-111, PDBID: 1J7V, Subunit R, Seq Identity:100%, Tissue factor

UniProt annotation for I10R1_HUMAN » Interleukin-10 receptor subunit alpha
FUNCTION: Receptor for IL10; binds IL10 with a high affinity.

TISSUE SPECIFICITY: Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.

DISEASE: Inflammatory bowel disease 28 (IBD28) OMIM: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. mutations affecting the gene represented in this entry.

UniProt features for I10R1_HUMAN » Interleukin-10 receptor subunit alpha
SIGNAL 1 21
CHAIN 22 578 Interleukin-10 receptor subunit alpha.
DISULFID 56 75
DISULFID 202 223
Amino Acid Sequence for I10R1_HUMAN » Interleukin-10 receptor subunit alpha
MLPCLVVLLA ALLSLRLGSD AHGTELPSPP SVWFEAEFFH HILHWTPIPN QSESTCYEVA LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV RAVDGSRHSN WTVTNTRFSV DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM APANDTYESI FSHFREYEIA IRKVPGNFTF THKKVKHENF SLLTSGEVGE FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTNVIIFF AFVLLLSGAL AYCLALQLYV RRRKKLPSVL LFKKPSPFIF ISQRPSPETQ DTIHPLDEEA FLKVSPELKN LDLHGSTDSG FGSTKPSLQT EEPQFLLPDP HPQADRTLGN GEPPVLGDSC SSGSSNSTDS GICLQEPSLS PSTGPTWEQQ VGSNSRGQDD SGIDLVQNSE GRAGDTQGGS ALGHHSPPEP EVPGEEDPAA VAFQGYLRQT RCAEEKATKT GCLEEESPLT DGLGPKFGRC LVDEAGLHPP ALAKGYLKQD PLEMTLASSG APTGQWNQPT EEWSLLALSS CSDLGISDWS FAHDLAPLGC VAAPGGLLGS FNSDLVTLPL ISSLQSSE