HRD3A_ARATH » ERAD-associated E3 ubiquitin-protein ligase component HRD3A

HRD3A_ARATH » ERAD-associated E3 ubiquitin-protein ligase component HRD3A
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
HRD3A_ARATH » ERAD-associated E3 ubiquitin-protein ligase component HRD3A »
Hydrophobic Thickness 29.8 ± 2.8 Å
Tilt Angle 2 ± 6°
ΔGtransfer -18.9 kcal/mol
ΔGfold -11.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 625-645 (623-648)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 242-278, PDBID: 1OUV, Subunit A, Seq Identity:33%, Sel1 repeat

AA: 279-314, PDBID: 1OUV, Subunit A, Seq Identity:40%, Sel1 repeat

AA: 319-351, PDBID: 1KLX, Subunit A, Seq Identity:44%, Sel1 repeat

AA: 352-387, PDBID: 1OUV, Subunit A, Seq Identity:41%, Sel1 repeat

AA: 388-423, PDBID: 1KLX, Subunit A, Seq Identity:35%, Sel1 repeat

AA: 504-533, PDBID: 3RJV, Subunit A, Seq Identity:42%, Sel1 repeat

AA: 540-572, PDBID: 3RJV, Subunit A, Seq Identity:42%, Sel1 repeat

UniProt annotation for HRD3A_ARATH » ERAD-associated E3 ubiquitin-protein ligase component HRD3A
FUNCTION: Component of the endoplasmic reticulum (ER) quality control system called ER-associated degradation (ERAD) and involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Functions as an ERAD substrate- recruiting factor that recognizes misfolded proteins for the HRD1 E3 ubiquitin ligase complex. Targets the misfolded LRR receptor kinase BRI1.

SUBUNIT: Interacts with OS9.

UniProt features for HRD3A_ARATH » ERAD-associated E3 ubiquitin-protein ligase component HRD3A
SIGNAL 1 25
CHAIN 26 678 ERAD-associated E3 ubiquitin-protein ligase component HRD3A.
REPEAT 124 159 Sel1-like 1.
REPEAT 242 277 Sel1-like 2.
REPEAT 279 313 Sel1-like 3.
REPEAT 317 349 Sel1-like 4.
REPEAT 353 386 Sel1-like 5.
REPEAT 388 422 Sel1-like 6.
REPEAT 506 537 Sel1-like 7.
REPEAT 540 568 Sel1-like 8.
Amino Acid Sequence for HRD3A_ARATH » ERAD-associated E3 ubiquitin-protein ligase component HRD3A
MRILSYGIVI LSLLVFSFIE FGVHARPVVL VLSNDDLNSG GDDNGVGESS DFDEFGESEP KSEEELDPGS WRSIFEPDDS TVQAASPQYY SGLKKILSAA SEGNFRLMEE AVDEIEAASS AGDPHAQSIM GFVYGIGMMR EKSKSKSFLH HNFAAAGGNM QSKMALAFTY LRQDMHDKAV QLYAELAETA VNSFLISKDS PVVEPTRIHS GTEENKGALR KSRGEEDEDF QILEYQAQKG NANAMYKIGL FYYFGLRGLR RDHTKALHWF LKAVDKGEPR SMELLGEIYA RGAGVERNYT KALEWLTLAA KEGLYSAFNG IGYLYVKGYG VDKKNYTKAR EYFEKAVDNE DPSGHYNLGV LYLKGIGVNR DVRQATKYFF VAANAGQPKA FYQLAKMFHT GVGLKKNLEM ATSFYKLVAE RGPWSSLSRW ALEAYLKGDV GKALILYSRM AEMGYEVAQS NAAWILDKYG ERSMCMGVSG FCTDKERHER AHSLWWRASE QGNEHAALLI GDAYYYGRGT ERDFVRAAEA YMHAKSQSNA QAMFNLGYMH EHGQGLPFDL HLAKRYYDES LQSDAAARLP VTLALASLWL RRNYADTVLV RVVDSLPEVY PKVETWIENV VFEEGNATIL TLFVCLITIL YLRERQRRQV VVVADPVAAD VAQPLDADVA QHLAAFPR