HPH2_YEAST » Protein HPH2

HPH2_YEAST » Protein HPH2
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
HPH2_YEAST » Protein HPH2 » Functionally related to TCP1 protein 2;High pH protein 2;
Hydrophobic Thickness 28.6 ± 2.0 Å
Tilt Angle 31 ± 3°
ΔGtransfer -23.6 kcal/mol
ΔGfold -14.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 504-522 (504-527)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ERP3, Complex: ERP3:HPH2

FMP32, Complex: FMP32:HPH2

HPH1, Complex: HPH2:HPH1, PubMed

IRE1, Complex: IRE1:HPH2, PubMed

RMD8, Complex: GPA2:DNM1:NADE:G3P1:DHOM:PPID:DIG2:HS104:HSC82:AHA1:UTP20:HSP82:CNS1:YBK4:2A5D:STI1:BUD3:PAM1:PPT1:RMD8:SMT3:RM50:MBB1:YN073:HPH2:STP4, PubMed

SEC66, Complex: SEC66:HPH2, PubMed

Domains

AA: 86-280, Sec63/Sec62 complex-interacting family

UniProt annotation for HPH2_YEAST » Protein HPH2
FUNCTION: Required for growth under high NaCl, alkaline pH and cell wall stress.

SUBUNIT: Interacts with HPH1/FRT1.

UniProt features for HPH2_YEAST » Protein HPH2
CHAIN 1 528 Protein HPH2.
Amino Acid Sequence for HPH2_YEAST » Protein HPH2
MQNAQIKSSS KGSGIDGTDR NSKDGVEKRP LEDVKQMIDA GTPDVGHKST VETKPNVGWQ ASHSNLAALH EKEQKYEMEH HHARHKLHRQ VIPDYTSAST AMFSDCMFNA APDKVRSLST MKSSGLSPKH PFNVVATFKG PFPQHSVESK PLDGGYSAKD HFPSFKMLQA QQHPAHRHYK DNDKYGLKSP SRSFVKDKKR LVHRFLKSME PSSSGQSKDS SALAPAFDPI LPNVISKPSK RPTHHSHSSD GSSSTQTDIS LQSLLYHDLE SSPKKHVSPS RPPSVASESS PAVANPIGLS PKDACNASFS QSSSSSLSSS SSSSSSTSFS QSVAVDPLEP PGNITYSSSN LSLNSDELDY YQRHIGLQLQ QTEALLKHSL KDEVLKDEND LVKNIANFDK IVKELRDLRS RTIGWKELVE EDYLMNLKQD FDKENPESFE ARLSDTINTN VAKLQDLEKR MASCKDRLAS RKEVMRKMES LLSLENSLMI SKKNVTFASK YRNEALDIVF LIIIIVICYT FKHLVSHK