HPH1_YEAST » Protein HPH1

HPH1_YEAST » Protein HPH1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
HPH1_YEAST » Protein HPH1 » Functionally related to TCP1 protein 1;High pH protein 1;
Hydrophobic Thickness 28.4 ± 1.4 Å
Tilt Angle 3 ± 0°
ΔGtransfer -34.5 kcal/mol
ΔGfold -12.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 574-596 (569-597)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ANP1, Complex: HPH1:ANP1

ATG32, Complex: ATG32:HPH1

ERG2, Complex: ERG2:HPH1

ERP3, Complex: ERP3:HPH1

FMP32, Complex: FMP32:HPH1

HPH2, Complex: HPH2:HPH1, PubMed

SEC66, Complex: SEC66:HPH1, PubMed

VOA1, Complex: VOA1:HPH1

YHO0, Complex: YHO0:HPH1

Domains

AA: 129-309, Sec63/Sec62 complex-interacting family

UniProt annotation for HPH1_YEAST » Protein HPH1
FUNCTION: Calcineurin-dependent protein required for growth under high NaCl, alkaline pH and cell wall stress.

SUBUNIT: Interacts with the 2 calcineurin A subunits CNA1 and CMP2, and with HPH2/FRT2.

MISCELLANEOUS: Present with 251 molecules/cell in log phase SD medium.

UniProt features for HPH1_YEAST » Protein HPH1
CHAIN 1 602 Protein HPH1.
Amino Acid Sequence for HPH1_YEAST » Protein HPH1
MNLLIDRMEN PGSRNCTLLP PSFPRGFCKG RRASSGDAVK IKESGLQPQP QPEPLQAKTN VAHFSKSSSR LPVIAVNDNP VVPRPSTEVN LGSLLQKERE KEKEEQPALH DRRHLYVTKN RAHGVRQRSL EMTSLPVLGS TKTGKFSDFL FEDDIDNRVG RHSRSYSGAS SLDDPFRVSP KTDFNSNRAR LSCLSKGRRG SMSVFQSCHT GLAFNQIQGS SSSQRRSSAG SFDYERKRLV NQFLQPSLGN SDPFDTLRES VVFEPSSTAG GIKLGNMHSQ SQISVNSSPS TSLFYHDLDG SAVNDSSSFL YSRSNVPAFL SSSAFSSTSS TSSDSEDVDR RSLNGVYPSL GYLTNQRKPR NSSGSSTAPG TDTLGFKYLL NRQKSADSST RFKSVLKVNN NNGSAATPDS SSNSISKSNS NLNDNIDELN YYQNHISTLL VKIENEMRRN LNDTIIKNEN NVQKTIQKYD LLSGELTLLL DEMTTLRTTV INQFLVKLKS DFDEDDNKAF INELKISVEE SVAQLQGLER RMEVCQERLN KQKSSLREMD SLIELKNVLN KSKNNTKSIY LYRYFIIDII AFLLMGGFIV YVKNLLTRFF TR