HMR1_HUMAN » Major histocompatibility complex class I-related gene protein

HMR1_HUMAN » Major histocompatibility complex class I-related gene protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
HMR1_HUMAN » Major histocompatibility complex class I-related gene protein » MHC class I-related gene protein; Class I histocompatibility antigen-like protein;
Hydrophobic Thickness 34.0 ± 3.0 Å
Tilt Angle 19 ± 15°
ΔGtransfer -20.6 kcal/mol
ΔGfold -13.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 300-324 (299-326)
Pathways

3-phosphoinositide degradation (BioCyc)

D-myo-inositol-5-phosphate metabolism (BioCyc)

PDB 4l4t (A/C=23-292), 4pjx (A/C=23-292), 4pji (A/C=23-292), 4pjh (A/C=23-292), 4pjg (A/C=23-292), 4pjf (A/C=23-292), 4pje (A/C=23-292), 4pjd (A/C=23-292), 4pjc (A/C=23-292), 4pjb (A/C=23-292), 4pja (A/C=23-292), 4pj7 (A/C=23-292), 4pj5 (A/C=23-292), 4nqe (A/C=23-292), 4nqd (A/C=23-292), 4nqc (A/C=23-292), 4lcw (A/C=23-292), 4l4v (A/C=23-292), 4gup (A/C=23-292), 4pj9 (A=23-292), 4pj8 (A=23-292)
OPM none
Complexes

Q6P4G7:HMR1:TRBC1:B2MG_HUMAN

Interactions

FATE1, Complex: HMR1:FATE1

TRBC1, Complex: HMR1:B2MG:Q6P4G7:TRBC1, PDBID: 4IIQ

Domains

AA: 23-198, PDBID: 4GUP, Subunit A, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 204-285, PDBID: 4GUP, Subunit C, Seq Identity:100%, Immunoglobulin C1-set domain

UniProt annotation for HMR1_HUMAN » Major histocompatibility complex class I-related gene protein
FUNCTION: Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T- cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.

SUBUNIT: Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3. Isoform 3/MR1B homodimerizes and doesn"t associates with B2M nor proteins of the peptide-loading complex.

TISSUE SPECIFICITY: Ubiquitous.

DOMAIN: The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression. The alpha-3 region mediates interaction with B2M (PubMed).

DOMAIN: The ligand-binding groove is ideally suited to present small organic compounds that can originate from vitamins rather than antigenic peptides.

MISCELLANEOUS: MR1 is detected in an open versus folded conformation. Only the folded MR1 conformer activates MAIT cells.

UniProt features for HMR1_HUMAN » Major histocompatibility complex class I-related gene protein
SIGNAL 1 22
CHAIN 23 341 Major histocompatibility complex class I- related gene protein.
DOMAIN 203 299 Ig-like C1-type.
REGION 23 201 Ligand-binding.
REGION 23 109 Alpha-1.
REGION 110 201 Alpha-2.
REGION 202 293 Alpha-3.
REGION 294 302 Connecting peptide.
DISULFID 222 278 By similarity.
Amino Acid Sequence for HMR1_HUMAN » Major histocompatibility complex class I-related gene protein
MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV DSHPITTYDS VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK RLQRHYNHSG SHTYQRMIGC ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS WLAVDNVAHT IKQAWEANQH ELLYQKNWLE EECIAWLKRF LEYGKDTLQR TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG EEIVQEIDYG DILPSGDGTY QAWASIELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R