HLPDA_HUMAN » Hypoxia-inducible lipid droplet-associated protein

HLPDA_HUMAN » Hypoxia-inducible lipid droplet-associated protein
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Topology in Lipid droplet
Topologylipid droplet interior
cytoplasmic side
HLPDA_HUMAN » Hypoxia-inducible lipid droplet-associated protein » Hypoxia-inducible gene 2 protein;
Hydrophobic Thickness 29.8 ± 3.5 Å
Tilt Angle 29 ± 0°
ΔGtransfer -18.9 kcal/mol
ΔGfold -10.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 4-25 (3-27)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 1-63, Hypoxia-inducible lipid droplet-associated

UniProt annotation for HLPDA_HUMAN » Hypoxia-inducible lipid droplet-associated protein
FUNCTION: Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.

TISSUE SPECIFICITY: Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level).

INDUCTION: By hypoxia but highly abundant under normoxic conditions (at protein level).

UniProt features for HLPDA_HUMAN » Hypoxia-inducible lipid droplet-associated protein
CHAIN 1 63 Hypoxia-inducible lipid droplet- associated protein.
REGION 1 37 Required for targeting to lipid droplets.
Amino Acid Sequence for HLPDA_HUMAN » Hypoxia-inducible lipid droplet-associated protein
MKHVLNLYLL GVVLTLLSIF VRVMESLEGL LESPSPGTSW TTRSQLANTE PTKGLPDHPS RSM