HLAH_HUMAN » Putative HLA class I histocompatibility antigen, alpha chain H

HLAH_HUMAN » Putative HLA class I histocompatibility antigen, alpha chain H
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
HLAH_HUMAN » Putative HLA class I histocompatibility antigen, alpha chain H » HLA-12.4;HLA-AR;MHC class I antigen H;
Hydrophobic Thickness 38.4 ± 1.0 Å
Tilt Angle 3 ± 0°
ΔGtransfer -48.0 kcal/mol
ΔGfold -22.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 305-333 (305-339)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 25-203, PDBID: 1E27, Subunit A, Seq Identity:82%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 208-290, PDBID: 1Q94, Subunit D, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 337-362, PDBID: 4EMZ, Subunit D, Seq Identity:89%, MHC_I C-terminus

UniProt annotation for HLAH_HUMAN » Putative HLA class I histocompatibility antigen, alpha chain H
FUNCTION: Involved in the presentation of foreign antigens to the immune system.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin).

UniProt features for HLAH_HUMAN » Putative HLA class I histocompatibility antigen, alpha chain H
SIGNAL 1 24 Potential.
CHAIN 25 362 Putative HLA class I histocompatibility antigen, alpha chain H.
DOMAIN 209 297 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 308 Connecting peptide.
DISULFID 227 283 By similarity.
Amino Acid Sequence for HLAH_HUMAN » Putative HLA class I histocompatibility antigen, alpha chain H
MAVMAPRTLL LLLSGALALT QTWARSHSMR YFYTTMSRPG AGEPRFISVG YVDDTQFVRF DSDDASPREE PRAPWMEREG PKYWDRNTQI CKAQAQTERE NLRIALRYYN QSEGGSHTMQ VMYGCDVGPD GPFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAARRAEQR RVYLEGEFVE WLRRYLENGK ETLQRADPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTVPIVG IVAGLVLLVA VVTGAVVAAV MWRKKSSDRK GGSYSQAASS NSAQGSDVSL TA