HLAG_HUMAN » HLA class I histocompatibility antigen, alpha chain G

HLAG_HUMAN » HLA class I histocompatibility antigen, alpha chain G
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
HLAG_HUMAN » HLA class I histocompatibility antigen, alpha chain G » HLA G antigen;MHC class I antigen G;
Hydrophobic Thickness 38.0 ± 1.2 Å
Tilt Angle 0 ± 1°
ΔGtransfer -45.5 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 305-333 (305-336)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB 3kyo (A/C=26-298), 2d31 (A/D=25-300), 2dyp (A=25-300), 3kyn (A=26-299), 1ydp (A=26-300), 3cii (C/F=3-11), 3bze (P/Q/R/S=3-11), 3cdg (P/Q=3-11)
OPM none
Complexes

HLAE:NKG2A:KLRD1:HLAG:B2MG_HUMAN

LIRB2:HLAG:H2AX:B2MG_HUMAN

HLAE:HLAG:B2MG_HUMAN

Interactions

1A66, Complex: 1A66:HLAG, PubMed

CD8A, Complex: CD8A:HLAG, PubMed

HLAE, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

KI2L4, Complex: KI2L4:HLAG, PubMed

KLRD1, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

LIRB1, Complex: HLAG:LIRB1, PubMed

LIRB2, Complex: B2MG:HLAG:LIRB2, PDBID: 2dyp

NKG2A, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

Domains

AA: 25-203, PDBID: 1YDP, Subunit A, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 208-290, PDBID: 1YDP, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

UniProt annotation for HLAG_HUMAN » HLA class I histocompatibility antigen, alpha chain G
FUNCTION: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Homodimer; disulfide-linked. Binds to LILRB1 and LILRB2.

TISSUE SPECIFICITY: Expressed in trophoblasts.

UniProt features for HLAG_HUMAN » HLA class I histocompatibility antigen, alpha chain G
SIGNAL 1 24
CHAIN 25 338 HLA class I histocompatibility antigen, alpha chain G.
DOMAIN 209 299 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 308 Connecting peptide.
DISULFID 66 66 Interchain.
DISULFID 125 188
DISULFID 227 283
Amino Acid Sequence for HLAG_HUMAN » HLA class I histocompatibility antigen, alpha chain G
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD