HLAF_HUMAN » HLA class I histocompatibility antigen, alpha chain F

HLAF_HUMAN » HLA class I histocompatibility antigen, alpha chain F
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
HLAF_HUMAN » HLA class I histocompatibility antigen, alpha chain F » CDA12;HLA F antigen;Leukocyte antigen F;MHC class I antigen F;
Hydrophobic Thickness 38.8 ± 1.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -43.1 kcal/mol
ΔGfold -19.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 302-330 (302-335)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB none
OPM none
Complexes none
Interactions

LIRB1, Complex: LIRB1:HLAF, PubMed

LIRB2, Complex: HLAF:LIRB2, PubMed

Domains

AA: 22-200, PDBID: 1HSA, Subunit A, Seq Identity:77%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 206-287, PDBID: 1Q94, Subunit D, Seq Identity:91%, Immunoglobulin C1-set domain

UniProt annotation for HLAF_HUMAN » HLA class I histocompatibility antigen, alpha chain F
FUNCTION: Involved in the presentation of foreign antigens to the immune system.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin).

UniProt features for HLAF_HUMAN » HLA class I histocompatibility antigen, alpha chain F
SIGNAL 1 21
CHAIN 22 346 HLA class I histocompatibility antigen, alpha chain F.
DOMAIN 206 296 Ig-like C1-type.
REGION 22 111 Alpha-1.
REGION 112 203 Alpha-2.
REGION 204 295 Alpha-3.
REGION 296 305 Connecting peptide.
DISULFID 122 185 By similarity.
DISULFID 224 280 By similarity.
Amino Acid Sequence for HLAF_HUMAN » HLA class I histocompatibility antigen, alpha chain F
MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPQP LILRWEQSPQ PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAV