HLAE_HUMAN » HLA class I histocompatibility antigen, alpha chain E

HLAE_HUMAN » HLA class I histocompatibility antigen, alpha chain E
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
HLAE_HUMAN » HLA class I histocompatibility antigen, alpha chain E » MHC class I antigen E;
Hydrophobic Thickness 42.4 ± 4.2 Å
Tilt Angle 11 ± 3°
ΔGtransfer -20.8 kcal/mol
ΔGfold -16.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 302-329 (302-333)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB 3am8 (A/B=22-297), 3bze (A/C/E/G=23-295), 1kpr (A/C=22-295), 1ktl (A/C=22-295), 1mhe (A/C=22-295), 3bzf (A/C=22-297), 3cdg (A/C=23-295), 3cii (A/D=23-295), 2esv (A=23-297)
OPM none
Complexes

HLAE:NKG2A:KLRD1:HLAG:B2MG_HUMAN

UL40:HLAE:TCA:TRBC1:B2MG_HUMAN

1C07:HLAE:B2MG_HUMAN

HLAE:HLAG:B2MG_HUMAN

Interactions

1C07, Complex: 1C07:B2MG:HLAE, PDBID: 3bzf

CALX, Complex: HLAF:CALX:HLAE:PDIA3:CALR:B2MG:HLAG:TPSN, PubMed

CD8A, Complex: HLAE:CD8A, PubMed

HLAG, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

KLRD1, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

NKG2A, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

TCA, Complex: B2MG:HLAE:TCA, PDBID: 2esv

Domains

AA: 22-200, PDBID: 1KPR, Subunit A, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 206-287, PDBID: 1KPR, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 334-355, PDBID: 4EMZ, Subunit D, Seq Identity:53%, MHC_I C-terminus

UniProt annotation for HLAE_HUMAN » HLA class I histocompatibility antigen, alpha chain E
FUNCTION: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin).

UniProt features for HLAE_HUMAN » HLA class I histocompatibility antigen, alpha chain E
SIGNAL 1 21
CHAIN 22 358 HLA class I histocompatibility antigen, alpha chain E.
DOMAIN 206 294 Ig-like C1-type.
REGION 22 111 Alpha-1.
REGION 112 203 Alpha-2.
REGION 204 295 Alpha-3.
REGION 296 305 Connecting peptide.
DISULFID 122 185
DISULFID 224 280
Amino Acid Sequence for HLAE_HUMAN » HLA class I histocompatibility antigen, alpha chain E
MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH GCELGPDRRF LRGYEQFAYD GKDYLTLNED LRSWTAVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA QGSESHSL