HKR1_YEAST » Signaling mucin HKR1

HKR1_YEAST » Signaling mucin HKR1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
HKR1_YEAST » Signaling mucin HKR1 » Hansenula MRAKII killer toxin-resistant protein 1;
Hydrophobic Thickness 37.6 ± 4.8 Å
Tilt Angle 30 ± 0°
ΔGtransfer -34.3 kcal/mol
ΔGfold -29.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 1483-1508 (1475-1510)
Pathways none
PDB none
OPM none
Complexes none
Interactions

EMP24, Complex: EMP24:HKR1

MID2, Complex: HKR1:MID2

MNN10, Complex: MNN10:HKR1

OPY2, Complex: HKR1:OPY2

YO08A, Complex: YO08A:HKR1

Domains none
UniProt annotation for HKR1_YEAST » Signaling mucin HKR1
FUNCTION: Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. May regulate beta- glucan synthesis. Overexpression provides resistance to HM-1 killer toxin.

INDUCTION: Expression is highly increased during spheroplast regeneration.

UniProt features for HKR1_YEAST » Signaling mucin HKR1
SIGNAL 1 21 Potential.
CHAIN 22 1802 Signaling mucin HKR1.
REPEAT 453 480 1; approximate.
REPEAT 481 508 2.
REPEAT 509 536 3.
REPEAT 537 564 4.
REPEAT 565 592 5.
REPEAT 593 620 6.
REPEAT 621 648 7.
REPEAT 649 676 8.
REPEAT 677 704 9.
REPEAT 705 732 10.
REPEAT 733 760 11.
REPEAT 761 788 12.
REGION 453 788 12 X 28 AA tandem repeats of S-[AV]-[P]- V-A-V-S-S-T-Y-T-S-S-P-S-A-P-A-A-I-S-S-T- Y-T-S-S-P.
Amino Acid Sequence for HKR1_YEAST » Signaling mucin HKR1
MVSLKIKKIL LLVSLLNAIE AYSNDTIYST SYNNGIESTP SYSTSAISST GSSNKENAIT SSSETTTMAG QYGESGSTTI MDEQETGTSS QYISVTTTTQ TSDTMSSVKK STEIATPSSS IVPTPLQSYS DESQISQTLS HNPKSVAESD SDTTSSESSS SVIISTSDSS AVPREISPII TTDSQISKEE GTLAQTSSIS ETTRIAQMVT RVSQISSITA ASTIDGFSSE STQTDFSNTV SFENSVEEEY AMSKSQLSES YSSSSTVYSG GESTADKTSS SPITSFSSSY SQTTSTETSE SSRVAVGVSR PSSITQTTSI DSFSMSEVEL STYYDLSAGN YPDQELIVDR PATSSTAETS SEASQGVSRE SNTFAVSSIS TTNFIVSSAS DTVVSTSSTN TVPYSSVHST FVHATSSSTY ISSSLYSSPS LSASVSSHFG VAPFPSAYIS FSSVPVAVSS TYTSSPSASV VVPSAYASSP SVPVAVSSTY TSSPSAPAAI SSTYTSSPSA PVAVSSTYTS SPSAPAAISS TYTSSPSAPV AVSSTYTSSP SAPAAISSTY TSSPSAPVAV SSTYTSSPSA PVAISSTYTS SPSVPVAVSS TYTSSPSAPA AISSTYTSSP SAPVAVSSTY TSSPSAPAAI SSTYTSSPSV PVAVSSTYTS SPSAPAAISS TYTSSPSVPV AVSSTYTSSP SAPAAISSTY TSSPSAPVAV SSTYTSSPSA PAAISSTYTS SPSAPVAVSS TYTSSPSAPA AISSTYTSSP SAPVAVSSTY TSSPSALVVL SSTSTSSPYD IVYSPSTFAA ISSGYTPSPS ASVAMSSTSS SSPYDIVYSL SSSASRSSIA TYEFSPSPST SLPTSSTYTY FSSAYAFEFS SERYSTTSTI APTQIHSTLS RITDFLLQTS MAIQSIVSQQ ISTSSTLNDE IHSSALSVFN PSASNLVETS LIISSTQASI TSPKNSAKIS SLQSQLSSST KNPYDTANKN TETSGRSTVV SNFLYTSSAA KPDNEKFSAT PTEITTISSS SHAYSLSIPS SHNSVTGLSH NFVDSSKSAT SFGYSSSSIS SIKLSKETIP ASKSVSNTQE RITSFTSTLR ANSQSEKSEG RNSVGSLQSS HISSNPSLST NTKVDSKSLS RKVSKTMGEN GEETGLTTTK TQYKSSSETS GSYSRSFTKI SIGPATTAVQ TQASTNSVFT APALSTYPTT PYPSPNSYAW LPTAIIVESS ETGPTTASFN PSITGSLPNA IEPAVAVSEP INHTLITIGF TAALNYVFLV QNPLSSAQIF NFLPLVLKYP FSNTSSELDN SIGELSTFIL SYRSGSSTTT LSPKSISSLS VVKKKKNQQK KNATKSTEDL HPPQVDTSSI AVKKIVPMVD SSKAYIVSVA EVYFPTEAVT YLQQLILDEN STLYSNPQTP LRSLAGLIDS GIPLGGLTLY GSGDGGYVPS LTSSSVLDSS KGNSQNIDGT YKYGALDDFI NSFTDSASAG KYAVKIIIFL IVLTIGVLLW LFVAFFAFRH RNILLKRHPR NCIGKSLNNE RELESTELSR SSSGNQVYNE KPPESENESV YSAVDDHYIV TGENTVYNTI HRLHYTINDD GDLLYRDAIP LDFDQTNGDD GSGIDSIVRD CVYDKNQDAT EAFLNDEESI SGILDVDENG DIRLYDSYSD NEESNSFHLP DEVIENYNKN HLCETKLHGL GTESCTTDDP DTGNQITNEF STGSQTCLPS TAYTTPLHTN SIKLHTLRYT ESSLPKPNQT LFSNLEDLEI EDIDDNGSVS DVHIEELDAL DEELYKRMSK VIKQQNHQTT KI