HHLA2_HUMAN » HERV-H LTR-associating protein 2

HHLA2_HUMAN » HERV-H LTR-associating protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
HHLA2_HUMAN » HERV-H LTR-associating protein 2 » Human endogenous retrovirus-H long terminal repeat-associating protein 2;
Hydrophobic Thickness 34.8 ± 2.4 Å
Tilt Angle 1 ± 1°
ΔGtransfer -21.9 kcal/mol
ΔGfold -14.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 343-367 (341-377)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 36-139, PDBID: 1PKO, Subunit A, Seq Identity:27%, Immunoglobulin V-set domain

AA: 137-217, PDBID: 1K8I, Subunit A, Seq Identity:28%, Immunoglobulin C1-set domain

AA: 226-336, PDBID: 1HKF, Subunit A, Seq Identity:24%, Immunoglobulin V-set domain

UniProt annotation for HHLA2_HUMAN » HERV-H LTR-associating protein 2
FUNCTION: Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

SUBUNIT: Interacts with TMIGD2.

TISSUE SPECIFICITY: Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B- cells, dendritic cells and macrophages. Not detected in T-cells.

INDUCTION: Up-regulated in antigen-presenting cells in response to inflammation. Induced in dendritic cells in response to IFNG, poly(I:C) or heat-killed Listeria monocytogenes (at protein level).

UniProt features for HHLA2_HUMAN » HERV-H LTR-associating protein 2
SIGNAL 1 22 Potential.
CHAIN 23 414 HERV-H LTR-associating protein 2.
DOMAIN 61 131 Ig-like V-type 1.
DOMAIN 138 222 Ig-like C1-type.
DOMAIN 235 328 Ig-like V-type 2.
DISULFID 159 210 By similarity.
DISULFID 243 317 By similarity.
Amino Acid Sequence for HHLA2_HUMAN » HERV-H LTR-associating protein 2
MKAQTALSFF LILITSLSGS QGIFPLAFFI YVPMNEQIVI GRLDEDIILP SSFERGSEVV IHWKYQDSYK VHSYYKGSDH LESQDPRYAN RTSLFYNEIQ NGNASLFFRR VSLLDEGIYT CYVGTAIQVI TNKVVLKVGV FLTPVMKYEK RNTNSFLICS VLSVYPRPII TWKMDNTPIS ENNMEETGSL DSFSINSPLN ITGSNSSYEC TIENSLLKQT WTGRWTMKDG LHKMQSEHVS LSCQPVNDYF SPNQDFKVTW SRMKSGTFSV LAYYLSSSQN TIINESRFSW NKELINQSDF SMNLMDLNLS DSGEYLCNIS SDEYTLLTIH TVHVEPSQET ASHNKGLWIL VPSAILAAFL LIWSVKCCRA QLEARRSRHP ADGAQQERCC VPPGERCPSA PDNGEENVPL SGKV