HFLK_ECOLI » Modulator of FtsH protease HflK

HFLK_ECOLI » Modulator of FtsH protease HflK
Magnify HFLK_ECOLI » Modulator of FtsH protease HflKEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Bacterial Gram-negative inner membrane
Topologyextracellular side
cytoplasmic side
HFLK_ECOLI » Modulator of FtsH protease HflK »
Hydrophobic Thickness 32.8 ± 3.7 Å
Tilt Angle 13 ± 7°
ΔGtransfer -21.1 kcal/mol
ΔGfold -16.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 79-100 (79-105)
Pathways none
PDB none
OPM none
Complexes none
Interactions

FTSH, Complex: HFLK:FTSH, PubMed

Domains

AA: 1-59, Bacterial membrane protein N terminal

AA: 98-272, PDBID: 4FVF, Subunit A, Seq Identity:29%, SPFH domain / Band 7 family

UniProt annotation for HFLK_ECOLI » Modulator of FtsH protease HflK
FUNCTION: HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins.

SUBUNIT: HflC and HflK interact to form a complex, originally called HflA, now called HflKC. HflKC interacts with FtsH; complex formation is stimulated by ATP, and with YccA.

MISCELLANEOUS: Integration of this protein into the membrane depends on SecA, SecY and SecD but not on SecB or FtsY. HflK is unstable in the absence of HflC.

UniProt features for HFLK_ECOLI » Modulator of FtsH protease HflK
CHAIN 1 419 Modulator of FtsH protease HflK.
Amino Acid Sequence for HFLK_ECOLI » Modulator of FtsH protease HflK
MAWNQPGNNG QDRDPWGSSK PGGNSEGNGN KGGRDQGPPD LDDIFRKLSK KLGGLGGGKG TGSGGGSSSQ GPRPQLGGRV VTIAAAAIVI IWAASGFYTI KEAERGVVTR FGKFSHLVEP GLNWKPTFID EVKPVNVEAV RELAASGVML TSDENVVRVE MNVQYRVTNP EKYLYSVTSP DDSLRQATDS ALRGVIGKYT MDRILTEGRT VIRSDTQREL EETIRPYDMG ITLLDVNFQA ARPPEEVKAA FDDAIAAREN EQQYIREAEA YTNEVQPRAN GQAQRILEEA RAYKAQTILE AQGEVARFAK LLPEYKAAPE ITRERLYIET MEKVLGNTRK VLVNDKGGNL MVLPLDQMLK GGNAPAAKSD NGASNLLRLP PASSSTTSGA SNTSSTSQGD IMDQRRANAQ RNDYQRQGE