HEG1_HUMAN » Protein HEG homolog 1

HEG1_HUMAN » Protein HEG homolog 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
HEG1_HUMAN » Protein HEG homolog 1 »
Hydrophobic Thickness 34.4 ± 3.2 Å
Tilt Angle 41 ± 0°
ΔGtransfer -25.8 kcal/mol
ΔGfold -22.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1245-1273 (1245-1277)
Pathways none
PDB 3u7d (B/D=1356-1381), 4hdq (C=1356-1381)
OPM none
Complexes none
Interactions none
Domains

AA: 989-1021, PDBID: 3H5C, Subunit B, Seq Identity:44%, EGF-like domain

AA: 1025-1063, PDBID: 2RQZ, Subunit A, Seq Identity:56%, Calcium-binding EGF domain

UniProt annotation for HEG1_HUMAN » Protein HEG homolog 1
FUNCTION: Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions.

SUBUNIT: Interacts with CCM2 and KRIT1; KRIT1 markedly facilitates interaction with CCM2.

UniProt features for HEG1_HUMAN » Protein HEG homolog 1
SIGNAL 1 29 Potential.
CHAIN 30 1381 Protein HEG homolog 1.
DOMAIN 985 1023 EGF-like 1.
DOMAIN 1025 1063 EGF-like 2; calcium-binding (Potential).
DISULFID 989 1000 By similarity.
DISULFID 994 1011 By similarity.
DISULFID 1013 1022 By similarity.
DISULFID 1029 1040 By similarity.
DISULFID 1034 1049 By similarity.
DISULFID 1051 1062 By similarity.
Amino Acid Sequence for HEG1_HUMAN » Protein HEG homolog 1
MASPRASRWP PPLLLLLLPL LLLPPAAPGT RDPPPSPARR ALSLAPLAGA GLELQLERRP EREPPPTPPR ERRGPATPGP SYRAPEPGAA TQRGPSGRAP RGGSADAAWK HWPESNTEAH VENITFYQNQ EDFSTVSSKE GVMVQTSGKS HAASDAPENL TLLAETADAR GRSGSSSRTN FTILPVGYSL EIATALTSQS GNLASESLHL PSSSSEFDER IAAFQTKSGT ASEMGTERAM GLSEEWTVHS QEATTSAWSP SFLPALEMGE LTTPSRKRNS SGPDLSWLHF YRTAASSPLL DLSSSSESTE KLNNSTGLQS SSVSQTKTMH VATVFTDGGP RTLRSLTVSL GPVSKTEGFP KDSRIATTSS SVLLSPSAVE SRRNSRVTGN PGDEEFIEPS TENEFGLTSL RWQNDSPTFG EHQLASSSEV QNGSPMSQTE TVSRSVAPMR GGEITAHWLL TNSTTSADVT GSSASYPEGV NASVLTQFSD STVQSGGSHT ALGDRSYSES SSTSSSESLN SSAPRGERSI AGISYGQVRG TAIEQRTSSD HTDHTYLSST FTKGERALLS ITDNSSSSDI VESSTSYIKI SNSSHSEYSS FFHAQTERSN ISSYDGEYAQ PSTESPVLHT SNLPSYTPTI NMPNTSVVLD TDAEFVSDSS SSSSSSSSSS SSGPPLPLPS VSQSHHLFSS ILPSTRASVH LLKSTSDAST PWSSSPSPLP VSLTTSTSAP LSVSQTTLPQ SSSTPVLPRA RETPVTSFQT STMTSFMTML HSSQTADLKS QSTPHQEKVI TESKSPSLVS LPTESTKAVT TNSPLPPSLT ESSTEQTLPA TSTNLAQMSP TFTTTILKTS QPLMTTPGTL SSTASLVTGP IAVQTTAGKQ LSLTHPEILV PQISTEGGIS TERNRVIVDA TTGLIPLTSV PTSAKEMTTK LGVTAEYSPA SRSLGTSPSP QTTVVSTAED LAPKSATFAV QSSTQSPTTV SSSASVNSCA VNPCLHNGEC VADNTSRGYH CRCPPSWQGD DCSVDVNECL SNPCPSTAMC NNTQGSFICK CPVGYQLEKG ICNLVRTFVT EFKLKRTFLN TTVEKHSDLQ EVENEITKTL NMCFSALPSY IRSTVHASRE SNAVVISLQT TFSLASNVTL FDLADRMQKC VNSCKSSAEV CQLLGSQRRI FRAGSLCKRK SPECDKDTSI CTDLDGVALC QCKSGYFQFN KMDHSCRACE DGYRLENETC MSCPFGLGGL NCGNPYQLIT VVIAAAGGGL LLILGIALIV TCCRKNKNDI SKLIFKSGDF QMSPYAEYPK NPRSQEWGRE AIEMHENGST KNLLQMTDVY YSPTSVRNPE LERNGLYPAY TGLPGSRHSC IFPGQYNPSF ISDESRRRDY F