HECA2_HUMAN » HEPACAM family member 2

HECA2_HUMAN » HEPACAM family member 2
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
HECA2_HUMAN » HEPACAM family member 2 » Mitotic kinetics regulator;
Hydrophobic Thickness 26.8 ± 4.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -38.1 kcal/mol
ΔGfold -17.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 351-373 (351-375)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 148-223, PDBID: 2DKS, Subunit A, Seq Identity:33%, Immunoglobulin domain

UniProt annotation for HECA2_HUMAN » HEPACAM family member 2
FUNCTION: Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation.

TISSUE SPECIFICITY: Widely expressed.

UniProt features for HECA2_HUMAN » HEPACAM family member 2
SIGNAL 1 31 Potential.
CHAIN 32 462 HEPACAM family member 2.
DOMAIN 149 233 Ig-like C2-type 1.
DOMAIN 235 331 Ig-like C2-type 2.
DISULFID 170 219 By similarity.
DISULFID 270 315 By similarity.
Amino Acid Sequence for HECA2_HUMAN » HEPACAM family member 2
MGQDAFMEPF GDTLGVFQCK IYLLLFGACS GLKVTVPSHT VHGVRGQALY LPVHYGFHTP ASDIQIIWLF ERPHTMPKYL LGSVNKSVVP DLEYQHKFTM MPPNASLLIN PLQFPDEGNY IVKVNIQGNG TLSASQKIQV TVDDPVTKPV VQIHPPSGAV EYVGNMTLTC HVEGGTRLAY QWLKNGRPVH TSSTYSFSPQ NNTLHIAPVT KEDIGNYSCL VRNPVSEMES DIIMPIIYYG PYGLQVNSDK GLKVGEVFTV DLGEAILFDC SADSHPPNTY SWIRRTDNTT YIIKHGPRLE VASEKVAQKT MDYVCCAYNN ITGRQDETHF TVIITSVGLE KLAQKGKSLS PLASITGISL FLIISMCLLF LWKKYQPYKV IKQKLEGRPE TEYRKAQTFS GHEDALDDFG IYEFVAFPDV SGVSRIPSRS VPASDCVSGQ DLHSTVYEVI QHIPAQQQDH PE