HBEGF_HUMAN » Proheparin-binding EGF-like growth factor

HBEGF_HUMAN » Proheparin-binding EGF-like growth factor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
HBEGF_HUMAN » Proheparin-binding EGF-like growth factor »
Hydrophobic Thickness 41.6 ± 2.2 Å
Tilt Angle 8 ± 6°
ΔGtransfer -30.3 kcal/mol
ΔGfold -24.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 159-186 (157-189)
Pathways

Epithelial cell signaling in Helicobacter pylori infection (KEGG)

ErbB signaling pathway (KEGG)

Estrogen signaling pathway (KEGG)

GnRH signaling pathway (KEGG)

Immune System (Reactome)

Proteoglycans in cancer (KEGG)

Signal Transduction (Reactome)

PDB 2m8s (B=185-208), 1xdt (R=73-147)
OPM none
Complexes none
Interactions

CD44, Complex: HBEGF:CD44, PubMed

EGFR, Complex: HBEGF:EGFR, PubMed

ERBB4, Complex: ERBB4:HBEGF, PubMed

Domains

AA: 108-142, PDBID: 1XDT, Subunit R, Seq Identity:100%, EGF-like domain

UniProt annotation for HBEGF_HUMAN » Proheparin-binding EGF-like growth factor
FUNCTION: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

SUBUNIT: Interacts with FBLN1 (By similarity). Interacts with EGFR and ERBB4.

UniProt features for HBEGF_HUMAN » Proheparin-binding EGF-like growth factor
SIGNAL 1 19 Potential.
CHAIN 20 208 Proheparin-binding EGF-like growth factor.
PROPEP 20 62 Or 72, or 73, or 76, or 81.
CHAIN 63 148 Heparin-binding EGF-like growth factor.
PROPEP 149 208 C-terminal (Potential).
DOMAIN 104 144 EGF-like.
SITE 141 141 Plays a critical role in diphtheria toxin binding and toxin sensitivity (By similarity).
DISULFID 108 121 By similarity.
DISULFID 116 132 By similarity.
DISULFID 134 143 By similarity.
Amino Acid Sequence for HBEGF_HUMAN » Proheparin-binding EGF-like growth factor
MKLLPSVVLK LFLAAVLSAL VTGESLERLR RGLAAGTSNP DPPTVSTDQL LPLGGGRDRK VRDLQEADLD LLRVTLSSKP QALATPNKEE HGKRKKKGKG LGKKRDPCLR KYKDFCIHGE CKYVKELRAP SCICHPGYHG ERCHGLSLPV ENRLYTYDHT TILAVVAVVL SSVCLLVIVG LLMFRYHRRG GYDVENEEKV KLGMTNSH