HAVR2_HUMAN » Hepatitis A virus cellular receptor 2

HAVR2_HUMAN » Hepatitis A virus cellular receptor 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
HAVR2_HUMAN » Hepatitis A virus cellular receptor 2 » HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3;TIMD-3; T-cell membrane protein 3;TIM-3;
Hydrophobic Thickness 36.4 ± 3.4 Å
Tilt Angle 4 ± 3°
ΔGtransfer -39.2 kcal/mol
ΔGfold -19.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 199-227 (195-232)
Pathways none
PDB 4qyc (A/B=22-126)
OPM 3kaa (MOUSE)
Complexes

CEAM1:HAVR2_HUMAN

Interactions

A4, Complex: A4:HAVR2, PubMed

CEAM1, Complex: CEAM1:HAVR2, PDBID: 4QYC

Domains

AA: 21-130, PDBID: 5F71, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for HAVR2_HUMAN » Hepatitis A virus cellular receptor 2
FUNCTION: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.

TISSUE SPECIFICITY: T-helper type 1 lymphocyte (Th1)-specific.

UniProt features for HAVR2_HUMAN » Hepatitis A virus cellular receptor 2
SIGNAL 1 21 Potential.
CHAIN 22 301 Hepatitis A virus cellular receptor 2.
DOMAIN 22 124 Ig-like V-type.
DISULFID 38 110 By similarity.
DISULFID 52 63 By similarity.
DISULFID 58 109 By similarity.
Amino Acid Sequence for HAVR2_HUMAN » Hepatitis A virus cellular receptor 2
MFSHLPFDCV LLLLLLLLTR SSEVEYRAEV GQNAYLPCFY TPAAPGNLVP VCWGKGACPV FECGNVVLRT DERDVNYWTS RYWLNGDFRK GDVSLTIENV TLADSGIYCC RIQIPGIMND EKFNLKLVIK PAKVTPAPTL QRDFTAAFPR MLTTRGHGPA ETQTLGSLPD INLTQISTLA NELRDSRLAN DLRDSGATIR IGIYIGAGIC AGLALALIFG ALIFKWYSHS KEKIQNLSLI SLANLPPSGL ANAVAEGIRS EENIYTIEEN VYEVEEPNEY YCYVSSRQQP SQPLGCRFAM P