HAVR1_HUMAN » Hepatitis A virus cellular receptor 1

HAVR1_HUMAN » Hepatitis A virus cellular receptor 1
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Topology in Plasma membrane
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cytoplasmic side
HAVR1_HUMAN » Hepatitis A virus cellular receptor 1 » HAVcr-1; Kidney injury molecule 1;KIM-1; T-cell immunoglobulin and mucin domain-containing protein 1;TIMD-1; T-cell membrane protein 1;TIM-1;TIM;
Hydrophobic Thickness 34.4 ± 2.0 Å
Tilt Angle 15 ± 3°
ΔGtransfer -25.2 kcal/mol
ΔGfold -17.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 292-316 (291-319)
Pathways none
PDB none
OPM 2or8 (MOUSE)
Complexes none
Interactions

SEM4A, Complex: HAVR1:SEM4A, PubMed

TIMD4, Complex: HAVR1:TIMD4, PubMed

Domains

AA: 20-124, PDBID: 5DZO, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for HAVR1_HUMAN » Hepatitis A virus cellular receptor 1
FUNCTION: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair.

TISSUE SPECIFICITY: Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.

INDUCTION: Up-regulated in the kidney in renal diseases (at protein level).

MISCELLANEOUS: The extracellular part of the protein can be cleaved and detected in urine and is in correlation with the expression in the kidney.

UniProt features for HAVR1_HUMAN » Hepatitis A virus cellular receptor 1
SIGNAL 1 20 Potential.
CHAIN 21 359 Hepatitis A virus cellular receptor 1.
DOMAIN 21 121 Ig-like V-type.
REPEAT 138 143 1.
REPEAT 144 149 2.
REPEAT 150 155 3.
REPEAT 156 160 4.
REPEAT 161 166 5.
REPEAT 167 172 6.
REPEAT 173 178 7.
REPEAT 179 184 8.
REPEAT 185 190 9.
REPEAT 191 196 10.
REPEAT 197 202 11.
REGION 138 202 11 X 6 AA approximate tandem repeats of V-P-T-T-T-T].
DISULFID 36 105 By similarity.
DISULFID 46 57 By similarity.
DISULFID 52 104 By similarity.
Amino Acid Sequence for HAVR1_HUMAN » Hepatitis A virus cellular receptor 1
MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG SCSLFTCQNG IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS GVYCCRVEHR GWFNDMKITV SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV PTTTTVPTTT VPTTMSIPTT TTVLTTMTVS TTTSVPTTTS IPTTTSVPVT TTVSTFVPPM PLPRQNHEPV ATSPSSPQPA ETHPTTLQGA IRREPTSSPL YSYTTDGNDT VTESSDGLWN NNQTQLFLEH SLLTANTTKG IYAGVCISVL VLLALLGVII AKKYFFKKEV QQLSVSFSSL QIKALQNAVE KEVQAEDNIY IENSLYATD