GSPA_ECOLI » Putative general secretion pathway protein A

GSPA_ECOLI » Putative general secretion pathway protein A
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Topology in Bacterial Gram-negative inner membrane
Topologyextracellular side
cytoplasmic side
GSPA_ECOLI » Putative general secretion pathway protein A »
Hydrophobic Thickness 29.6 ± 4.2 Å
Tilt Angle 32 ± 1°
ΔGtransfer -17.6 kcal/mol
ΔGfold -12.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 239-261 (232-264)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 15-140, PDBID: 1FNN, Subunit B, Seq Identity:25%, AAA domain

AA: 407-463, PDBID: 3BKH, Subunit A, Seq Identity:27%, Putative peptidoglycan binding domain

UniProt annotation for GSPA_ECOLI » Putative general secretion pathway protein A
FUNCTION: May play a regulatory role under conditions of derepressed gsp gene expression.

INDUCTION: Silenced by the DNA-binding protein H-NS under standard growth conditions.

MISCELLANEOUS: Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

UniProt features for GSPA_ECOLI » Putative general secretion pathway protein A
CHAIN 1 489 Putative general secretion pathway protein A.
Amino Acid Sequence for GSPA_ECOLI » Putative general secretion pathway protein A
MSTRREVILS WLCEKRQTWR LCYLLGEAGS GKTWLAQQLQ KDKHRRVITL SLVVSWQGKA AWIVTDDNAA EQGCRDSAWT RDEMAGQLLH ALHRTDSRCP LIIIENAHLN HRRILDDLQR AISLIPDGQF LLIGRPDRKV ERDFKKQGIE LVSIGRLTEH ELKASILEGQ NIDQPDLLLT ARVLKRIALL CRGDRRKLAL AGETIRLLQQ AEQTSVFTAK QWRMIYRILG DNRPRKMQLA VVMSGTIIAL TCGWLLLSSF TATLPVPAWL IPVTPVVKQD MTKDIAHVVM RDSEALSVLY GVWGYEVPAD SAWCDQAVRA GLACKSGNAS LQTLVDQNLP WIASLKVGDK KLPVVVVRVG EASVDVLVGQ QTWTLTHKWF ESVWTGDYLL LWKMSPEGES TITRDSSEEE ILWLETMLNR ALHISTEPSA EWRPLLVEKI KQFQKSHHLK TDGVVGFSTL VHLWQVAGES AYLYRDEANI SPETTVKGK