GSLG1_HUMAN » Golgi apparatus protein 1

GSLG1_HUMAN » Golgi apparatus protein 1
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
GSLG1_HUMAN » Golgi apparatus protein 1 » CFR-1;Cysteine-rich fibroblast growth factor receptor;E-selectin ligand 1;ESL-1; Golgi sialoglycoprotein MG-160;
Hydrophobic Thickness 30.4 ± 3.2 Å
Tilt Angle 8 ± 1°
ΔGtransfer -16.6 kcal/mol
ΔGfold -11.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1148-1168 (1141-1171)
Pathways

Cell adhesion molecules (KEGG)

PDB none
OPM none
Complexes none
Interactions

LYAM2, Complex: LYAM2:GSLG1, PubMed

Domains

AA: 153-212, Cysteine rich repeat

AA: 214-278, Cysteine rich repeat

AA: 289-346, Cysteine rich repeat

AA: 349-413, Cysteine rich repeat

AA: 417-473, Cysteine rich repeat

AA: 478-537, Cysteine rich repeat

AA: 540-604, Cysteine rich repeat

AA: 612-668, Cysteine rich repeat

AA: 669-729, Cysteine rich repeat

AA: 732-788, Cysteine rich repeat

AA: 799-856, Cysteine rich repeat

AA: 857-912, Cysteine rich repeat

AA: 915-979, Cysteine rich repeat

AA: 982-1042, Cysteine rich repeat

AA: 1044-1101, Cysteine rich repeat

UniProt annotation for GSLG1_HUMAN » Golgi apparatus protein 1
FUNCTION: Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils).

TISSUE SPECIFICITY: Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.

DEVELOPMENTAL STAGE: Expressed both in adult and fetal tissues.

UniProt features for GSLG1_HUMAN » Golgi apparatus protein 1
SIGNAL 1 29 Potential.
CHAIN 30 1179 Golgi apparatus protein 1.
REPEAT 116 149 Cys-rich GLG1 1.
REPEAT 150 212 Cys-rich GLG1 2.
REPEAT 215 278 Cys-rich GLG1 3.
REPEAT 286 346 Cys-rich GLG1 4.
REPEAT 347 413 Cys-rich GLG1 5.
REPEAT 414 473 Cys-rich GLG1 6.
REPEAT 475 537 Cys-rich GLG1 7.
REPEAT 538 604 Cys-rich GLG1 8.
REPEAT 609 668 Cys-rich GLG1 9.
REPEAT 670 728 Cys-rich GLG1 10.
REPEAT 729 788 Cys-rich GLG1 11.
REPEAT 796 856 Cys-rich GLG1 12.
REPEAT 858 911 Cys-rich GLG1 13.
REPEAT 912 979 Cys-rich GLG1 14.
REPEAT 980 1035 Cys-rich GLG1 15.
REPEAT 1041 1101 Cys-rich GLG1 16.
Amino Acid Sequence for GSLG1_HUMAN » Golgi apparatus protein 1
MAACGRVRRM FRLSAALHLL LLFAAGAEKL PGQGVHSQGQ GPGANFVSFV GQAGGGGPAG QQLPQLPQSS QLQQQQQQQQ QQQQPQPPQP PFPAGGPPAR RGGAGAGGGW KLAEEESCRE DVTRVCPKHT WSNNLAVLEC LQDVREPENE ISSDCNHLLW NYKLNLTTDP KFESVAREVC KSTITEIKEC ADEPVGKGYM VSCLVDHRGN ITEYQCHQYI TKMTAIIFSD YRLICGFMDD CKNDINILKC GSIRLGEKDA HSQGEVVSCL EKGLVKEAEE REPKIQVSEL CKKAILRVAE LSSDDFHLDR HLYFACRDDR ERFCENTQAG EGRVYKCLFN HKFEESMSEK CREALTTRQK LIAQDYKVSY SLAKSCKSDL KKYRCNVENL PRSREARLSY LLMCLESAVH RGRQVSSECQ GEMLDYRRML MEDFSLSPEI ILSCRGEIEH HCSGLHRKGR TLHCLMKVVR GEKGNLGMNC QQALQTLIQE TDPGADYRID RALNEACESV IQTACKHIRS GDPMILSCLM EHLYTEKMVE DCEHRLLELQ YFISRDWKLD PVLYRKCQGD ASRLCHTHGW NETSEFMPQG AVFSCLYRHA YRTEEQGRRL SRECRAEVQR ILHQRAMDVK LDPALQDKCL IDLGKWCSEK TETGQELECL QDHLDDLVVE CRDIVGNLTE LESEDIQIEA LLMRACEPII QNFCHDVADN QIDSGDLMEC LIQNKHQKDM NEKCAIGVTH FQLVQMKDFR FSYKFKMACK EDVLKLCPNI KKKVDVVICL STTVRNDTLQ EAKEHRVSLK CRRQLRVEEL EMTEDIRLEP DLYEACKSDI KNFCSAVQYG NAQIIECLKE NKKQLSTRCH QKVFKLQETE MMDPELDYTL MRVCKQMIKR FCPEADSKTM LQCLKQNKNS ELMDPKCKQM ITKRQITQNT DYRLNPMLRK ACKADIPKFC HGILTKAKDD SELEGQVISC LKLRYADQRL SSDCEDQIRI IIQESALDYR LDPQLQLHCS DEISSLCAEE AAAQEQTGQV EECLKVNLLK IKTELCKKEV LNMLKESKAD IFVDPVLHTA CALDIKHHCA AITPGRGRQM SCLMEALEDK RVRLQPECKK RLNDRIEMWS YAAKVAPADG FSDLAMQVMT SPSKNYILSV ISGSICILFL IGLMCGRITK RVTRELKDR