GPV_HUMAN » Platelet glycoprotein V

GPV_HUMAN » Platelet glycoprotein V
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
GPV_HUMAN » Platelet glycoprotein V » GPV; Glycoprotein 5;
Hydrophobic Thickness 36.4 ± 4.4 Å
Tilt Angle 34 ± 0°
ΔGtransfer -31.3 kcal/mol
ΔGfold -20.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 522-551 (520-557)
Pathways

ECM-receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

Hemostasis (Reactome)

PDB none
OPM none
Complexes none
Interactions

GP1BA, Complex: GP1BA:GPV, PubMed

GP1BB, Complex: GP1BA:GPIX:GP1BB:GPV, PubMed

GPIX, Complex: GP1BA:GPIX:GP1BB:GPV, PubMed

Domains

AA: 74-134, PDBID: 1OZN, Subunit A, Seq Identity:35%, Leucine rich repeat

AA: 98-158, PDBID: 4U7L, Subunit A, Seq Identity:42%, Leucine rich repeat

AA: 122-182, PDBID: 4RCA, Subunit B, Seq Identity:46%, Leucine rich repeat

AA: 146-192, PDBID: 4CNC, Subunit B, Seq Identity:44%, Leucine rich repeat

AA: 194-254, PDBID: 4U7L, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 364-422, PDBID: 4P8S, Subunit A, Seq Identity:39%, Leucine rich repeat

UniProt annotation for GPV_HUMAN » Platelet glycoprotein V
FUNCTION: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.

TISSUE SPECIFICITY: Platelets and megakaryocytes.

UniProt features for GPV_HUMAN » Platelet glycoprotein V
SIGNAL 1 16 Potential.
CHAIN 17 560 Platelet glycoprotein V.
DOMAIN 17 50 LRRNT.
REPEAT 75 96 LRR 1.
REPEAT 99 120 LRR 2.
REPEAT 123 144 LRR 3.
REPEAT 147 168 LRR 4.
REPEAT 171 193 LRR 5.
REPEAT 195 216 LRR 6.
REPEAT 219 240 LRR 7.
REPEAT 243 264 LRR 8.
REPEAT 267 288 LRR 9.
REPEAT 291 312 LRR 10.
REPEAT 340 361 LRR 11.
REPEAT 364 385 LRR 12.
REPEAT 388 409 LRR 13.
DOMAIN 421 474 LRRCT.
Amino Acid Sequence for GPV_HUMAN » Platelet glycoprotein V
MLRGTLLCAV LGLLRAQPFP CPPACKCVFR DAAQCSGGDV ARISALGLPT NLTHILLFGM GRGVLQSQSF SGMTVLQRLM ISDSHISAVA PGTFSDLIKL KTLRLSRNKI THLPGALLDK MVLLEQLFLD HNALRGIDQN MFQKLVNLQE LALNQNQLDF LPASLFTNLE NLKLLDLSGN NLTHLPKGLL GAQAKLERLL LHSNRLVSLD SGLLNSLGAL TELQFHRNHI RSIAPGAFDR LPNLSSLTLS RNHLAFLPSA LFLHSHNLTL LTLFENPLAE LPGVLFGEMG GLQELWLNRT QLRTLPAAAF RNLSRLRYLG VTLSPRLSAL PQGAFQGLGE LQVLALHSNG LTALPDGLLR GLGKLRQVSL RRNRLRALPR ALFRNLSSLE SVQLDHNQLE TLPGDVFGAL PRLTEVLLGH NSWRCDCGLG PFLGWLRQHL GLVGGEEPPR CAGPGAHAGL PLWALPGGDA ECPGPRGPPP RPAADSSSEA PVHPALAPNS SEPWVWAQPV TTGKGQDHSP FWGFYFLLLA VQAMITVIIV FAMIKIGQLF RKLIRERALG