GPVI_HUMAN » Platelet glycoprotein VI

GPVI_HUMAN » Platelet glycoprotein VI
Magnify GPVI_HUMAN » Platelet glycoprotein VIEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
GPVI_HUMAN » Platelet glycoprotein VI » GPVI; Glycoprotein 6;
Hydrophobic Thickness 33.8 ± 1.1 Å
Tilt Angle 12 ± 7°
ΔGtransfer -21.2 kcal/mol
ΔGfold -12.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 270-292 (269-295)
Pathways

ECM-receptor interaction (KEGG)

Hemostasis (Reactome)

PDB 2gi7 (A/B=21-203)
OPM none
Complexes

GPVI:GPVI_HUMAN

Interactions

FCERG, Complex: FCERG:GPVI, PubMed

FCG2A, Complex: GPVI:FCG2A, PubMed

FCG3A, Complex: FCG3A:GPVI, PubMed

GPVI, Complex: Homodimer of platelet glycoprotein VI, PDBID: 2GI7

Domains

AA: 27-107, PDBID: 2GI7, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 113-202, PDBID: 2GI7, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for GPVI_HUMAN » Platelet glycoprotein VI
FUNCTION: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.

SUBUNIT: Associated with Fc receptor gamma chain. The GPVI- FcRgamma complex is associated with the Src kinase family Fyn and Lyn.

TISSUE SPECIFICITY: Megakaryocytes and platelets.

DISEASE: Bleeding disorder, platelet-type 11 (BDPLT11) OMIM: A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. mutations affecting the gene represented in this entry.

UniProt features for GPVI_HUMAN » Platelet glycoprotein VI
SIGNAL 1 20 Potential.
CHAIN 21 339 Platelet glycoprotein VI.
DOMAIN 26 104 Ig-like C2-type 1.
DOMAIN 114 196 Ig-like C2-type 2.
DISULFID 48 88
DISULFID 134 180
Amino Acid Sequence for GPVI_HUMAN » Platelet glycoprotein VI
MSPSPTALFC LGLCLGRVPA QSGPLPKPSL QALPSSLVPL EKPVTLRCQG PPGVDLYRLE KLSSSRYQDQ AVLFIPAMKR SLAGRYRCSY QNGSLWSLPS DQLELVATGV FAKPSLSAQP GPAVSSGGDV TLQCQTRYGF DQFALYKEGD PAPYKNPERW YRASFPIITV TAAHSGTYRC YSFSSRDPYL WSAPSDPLEL VVTGTSVTPS RLPTEPPSSV AEFSEATAEL TVSFTNKVFT TETSRSITTS PKESDSPAGP ARQYYTKGNL VRICLGAVIL IILAGFLAED WHSRRKRLRH RGRAVQRPLP PLPPLPQTRK SHGGQDGGRQ DVHSRGLCS