GPNMB_HUMAN » Transmembrane glycoprotein NMB

GPNMB_HUMAN » Transmembrane glycoprotein NMB
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Topology in Melanosome membrane
Topologymelanosome lumenal side
cytoplasmic side
GPNMB_HUMAN » Transmembrane glycoprotein NMB » Transmembrane glycoprotein HGFIN;
Hydrophobic Thickness 30.2 ± 2.4 Å
Tilt Angle 7 ± 6°
ΔGtransfer -18.8 kcal/mol
ΔGfold -16.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 501-521 (499-525)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 270-321, PDBID: 2KZW, Subunit A, Seq Identity:42%, PKD domain

UniProt annotation for GPNMB_HUMAN » Transmembrane glycoprotein NMB
FUNCTION: Could be a melanogenic enzyme.

TISSUE SPECIFICITY: Up-regulated in various cancer cells, including in glioblastoma multiforme. Expressed in many melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). Hardly detectable in healthy brain.

DISEASE: Note=Glioblastoma multiforme patients that exhibit increased mRNA and protein levels (>3-fold over normal brain) in biopsy samples have a significantly higher risk of death (PubMed). In the context of cancer immunotherapy, including that of melanoma, has been proposed to be used as a cell surface protein antigen targeted by antibodies coupled to cytotoxic drugs (PubMed).

UniProt features for GPNMB_HUMAN » Transmembrane glycoprotein NMB
SIGNAL 1 21 Potential.
CHAIN 22 572 Transmembrane glycoprotein NMB.
DOMAIN 240 327 PKD.
MOTIF 64 66 Cell attachment site (Potential).
Amino Acid Sequence for GPNMB_HUMAN » Transmembrane glycoprotein NMB
MECLYYFLGF LLLAARLPLD AAKRFHDVLG NERPSAYMRE HNQLNGWSSD ENDWNEKLYP VWKRGDMRWK NSWKGGRVQA VLTSDSPALV GSNITFAVNL IFPRCQKEDA NGNIVYEKNC RNEAGLSADP YVYNWTAWSE DSDGENGTGQ SHHNVFPDGK PFPHHPGWRR WNFIYVFHTL GQYFQKLGRC SVRVSVNTAN VTLGPQLMEV TVYRRHGRAY VPIAQVKDVY VVTDQIPVFV TMFQKNDRNS SDETFLKDLP IMFDVLIHDP SHFLNYSTIN YKWSFGDNTG LFVSTNHTVN HTYVLNGTFS LNLTVKAAAP GPCPPPPPPP RPSKPTPSLA TTLKSYDSNT PGPAGDNPLE LSRIPDENCQ INRYGHFQAT ITIVEGILEV NIIQMTDVLM PVPWPESSLI DFVVTCQGSI PTEVCTIISD PTCEITQNTV CSPVDVDEMC LLTVRRTFNG SGTYCVNLTL GDDTSLALTS TLISVPDRDP ASPLRMANSA LISVGCLAIF VTVISLLVYK KHKEYNPIEN SPGNVVRSKG LSVFLNRAKA VFFPGNQEKD PLLKNQEFKG VS