GPA33_HUMAN » Cell surface A33 antigen

GPA33_HUMAN » Cell surface A33 antigen
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
GPA33_HUMAN » Cell surface A33 antigen » Glycoprotein A33;
Hydrophobic Thickness 35.2 ± 3.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -41.0 kcal/mol
ΔGfold -19.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 233-260 (231-264)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 25-138, PDBID: 3JZ7, Subunit A, Seq Identity:26%, Immunoglobulin V-set domain

AA: 139-215, PDBID: 3ALP, Subunit A, Seq Identity:32%, Immunoglobulin domain

UniProt annotation for GPA33_HUMAN » Cell surface A33 antigen
FUNCTION: May play a role in cell-cell recognition and signaling.

TISSUE SPECIFICITY: Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.

UniProt features for GPA33_HUMAN » Cell surface A33 antigen
SIGNAL 1 21
CHAIN 22 319 Cell surface A33 antigen.
DOMAIN 22 134 Ig-like V-type.
DOMAIN 140 227 Ig-like C2-type.
DISULFID 43 117 Potential.
DISULFID 146 222 Potential.
DISULFID 162 211 Potential.
Amino Acid Sequence for GPA33_HUMAN » Cell surface A33 antigen
MVGKMWPVLW TLCAVRVTVD AISVETPQDV LRASQGKSVT LPCTYHTSTS SREGLIQWDK LLLTHTERVV IWPFSNKNYI HGELYKNRVS ISNNAEQSDA SITIDQLTMA DNGTYECSVS LMSDLEGNTK SRVRLLVLVP PSKPECGIEG ETIIGNNIQL TCQSKEGSPT PQYSWKRYNI LNQEQPLAQP ASGQPVSLKN ISTDTSGYYI CTSSNEEGTQ FCNITVAVRS PSMNVALYVG IAVGVVAALI IIGIIIYCCC CRGKDDNTED KEDARPNREA YEEPPEQLRE LSREREEEDD YRQEEQRSTG RESPDHLDQ