GP2_HUMAN » Pancreatic secretory granule membrane major glycoprotein GP2

GP2_HUMAN » Pancreatic secretory granule membrane major glycoprotein GP2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
GP2_HUMAN » Pancreatic secretory granule membrane major glycoprotein GP2 » Pancreatic zymogen granule membrane protein GP-2;ZAP75;
Hydrophobic Thickness 33.4 ± 2.1 Å
Tilt Angle 3 ± 4°
ΔGtransfer -22.7 kcal/mol
ΔGfold -11.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 516-537 (515-537)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 229-478, PDBID: 4WRN, Subunit A, Seq Identity:43%, Zona pellucida-like domain

UniProt annotation for GP2_HUMAN » Pancreatic secretory granule membrane major glycoprotein GP2
SUBUNIT: Interacts with SYCN.
UniProt features for GP2_HUMAN » Pancreatic secretory granule membrane major glycoprotein GP2
SIGNAL 1 28

CHAIN 29 512 Pancreatic secretory granule membrane major glycoprotein GP2.

PROPEP 513 537 Removed in mature form.

DOMAIN 186 230 EGF-like.

DOMAIN 228 484 ZP.

DISULFID 190 200

DISULFID 194 209

DISULFID 211 229

DISULFID 401 461

Amino Acid Sequence for GP2_HUMAN » Pancreatic secretory granule membrane major glycoprotein GP2
MPHLMERMVG SGLLWLALVS CILTQASAVQ RGYGNPIEAS SYGLDLDCGA PGTPEAHVCF DPCQNYTLLD EPFRSTENSA GSQGCDKNMS GWYRFVGEGG VRMSETCVQV HRCQTDAPMW LNGTHPALGD GITNHTACAH WSGNCCFWKT EVLVKACPGG YHVYRLEGTP WCNLRYCTVP RDPSTVEDKC EKACRPEEEC LALNSTWGCF CRQDLNSSDV HSLQPQLDCG PREIKVKVDK CLLGGLGLGE EVIAYLRDPN CSSILQTEER NWVSVTSPVQ ASACRNILER NQTHAIYKNT LSLVNDFIIR DTILNINFQC AYPLDMKVSL QAALQPIVSS LNVSVDGNGE FIVRMALFQD QNYTNPYEGD AVELSVESVL YVGAILEQGD TSRFNLVLRN CYATPTEDKA DLVKYFIIRN SCSNQRDSTI HVEENGQSSE SRFSVQMFMF AGHYDLVFLH CEIHLCDSLN EQCQPSCSRS QVRSEVPAID LARVLDLGPI TRRGAQSPGV MNGTPSTAGF LVAWPMVLLT VLLAWLF