GOSR2_HUMAN » Golgi SNAP receptor complex member 2

GOSR2_HUMAN » Golgi SNAP receptor complex member 2
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
GOSR2_HUMAN » Golgi SNAP receptor complex member 2 » 27 kDa Golgi SNARE protein;Membrin;
Hydrophobic Thickness 30.2 ± 3.3 Å
Tilt Angle 2 ± 1°
ΔGtransfer -21.9 kcal/mol
ΔGfold -13.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 191-211 (188-211)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB 3eg9 (C=116-121)
OPM none
Complexes none
Interactions

A4, Complex: A4:GOSR2, PubMed

KASH5, Complex: GOSR2:KASH5

STX4, Complex: STX4:GOSR2

STX5, Complex: GOSR2:STX5, PubMed

STX6, Complex: STX6:GOSR2

Domains

AA: 121-186, PDBID: 4WY4, Subunit C, Seq Identity:19%, Snare region anchored in the vesicle membrane C-terminus

UniProt annotation for GOSR2_HUMAN » Golgi SNAP receptor complex member 2
FUNCTION: Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network.

SUBUNIT: Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6.

DISEASE: Epilepsy, progressive myoclonic 6 (EPM6) OMIM: A neurologic disorder characterized by onset of ataxia in the first years of life, followed by action myoclonus and seizures later in childhood, and loss of independent ambulation in the second decade. Cognition is not usually affected, although mild memory difficulties may occur in the third decade. mutations affecting the gene represented in this entry.

UniProt features for GOSR2_HUMAN » Golgi SNAP receptor complex member 2
CHAIN 1 212 Golgi SNAP receptor complex member 2.
COILED 61 107 Potential.
Amino Acid Sequence for GOSR2_HUMAN » Golgi SNAP receptor complex member 2
MDPLFQQTHK QVHEIQSCMG RLETADKQSV HIVENEIQAS IDQIFSRLER LEILSSKEPP NKRQNARLRV DQLKYDVQHL QTALRNFQHR RHAREQQERQ REELLSRTFT TNDSDTTIPM DESLQFNSSL QKVHNGMDDL ILDGHNILDG LRTQRLTLKG TQKKILDIAN MLGLSNTVMR LIEKRAFQDK YFMIGGMLLT CVVMFLVVQY LT