GOSR1_HUMAN » Golgi SNAP receptor complex member 1

GOSR1_HUMAN » Golgi SNAP receptor complex member 1
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
GOSR1_HUMAN » Golgi SNAP receptor complex member 1 » 28 kDa Golgi SNARE protein;28 kDa cis-Golgi SNARE p28;GOS-28;
Hydrophobic Thickness 29.6 ± 0.8 Å
Tilt Angle 0 ± 1°
ΔGtransfer -27.9 kcal/mol
ΔGfold -12.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 230-250 (230-250)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes none
Interactions

A4, Complex: GOSR1:A4, PubMed

ATAD1, Complex: ATAD1:GOSR1

BET1L, Complex: YKT6:STX5:BET1L:GOSR1, PubMed

BET1, Complex: GOSR1:BET1, PubMed

DSC1, Complex: GOSR1:DSC1, PubMed

I27RA, Complex: I27RA:GOSR1, PubMed

SC22B, Complex: GOSR1:SC22B, PubMed

STX12, Complex: STX12:GOSR1, PubMed

STX5, Complex: GOSR1:STX5, PubMed

Domains

AA: 161-226, PDBID: 1GL2, Subunit C, Seq Identity:17%, Snare region anchored in the vesicle membrane C-terminus

UniProt annotation for GOSR1_HUMAN » Golgi SNAP receptor complex member 1
FUNCTION: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.

SUBUNIT: Component of several multiprotein Golgi SNARE complexes. Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3. Interacts with GABARAPL2 (By similarity).

INDUCTION: Expression induced by hydrogen peroxide in neuronal cells. By monocrotaline in pulmonary epithelial cells (at protein level). Negatively regulated by OSBPL7 via GABARAPL2 leading to degradation on proteasomes (at protein level).

UniProt features for GOSR1_HUMAN » Golgi SNAP receptor complex member 1
CHAIN 1 250 Golgi SNAP receptor complex member 1.
COILED 9 30 Potential.
COILED 68 95 Potential.
Amino Acid Sequence for GOSR1_HUMAN » Golgi SNAP receptor complex member 1
MAAGTSSYWE DLRKQARQLE NELDLKLVSF SKLCTSYSHS STRDGRRDRY SSDTTPLLNG SSQDRMFETM AIEIEQLLAR LTGVNDKMAE YTNSAGVPSL NAALMHTLQR HRDILQDYTH EFHKTKANFM AIRERENLMG SVRKDIESYK SGSGVNNRRT ELFLKEHDHL RNSDRLIEET ISIAMATKEN MTSQRGMLKS IHSKMNTLAN RFPAVNSLIQ RINLRKRRDS LILGGVIGIC TILLLLYAFH</font>