GOGA5_HUMAN » Golgin subfamily A member 5

GOGA5_HUMAN » Golgin subfamily A member 5
Magnify GOGA5_HUMAN » Golgin subfamily A member 5Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
GOGA5_HUMAN » Golgin subfamily A member 5 » Cell proliferation-inducing gene 31 protein;Golgin-84;Protein Ret-II;RET-fused gene 5 protein;
Hydrophobic Thickness 35.6 ± 4.6 Å
Tilt Angle 4 ± 5°
ΔGtransfer -35.9 kcal/mol
ΔGfold -16.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 696-720 (695-720)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CASP, Complex: CASP.CUX1:GOGA5, PubMed

CASP, Complex: CASP:GOGA5, PubMed

RET, Complex: RET:GOGA5, PubMed

Domains

AA: 420-725, Golgin subfamily A member 5

UniProt annotation for GOGA5_HUMAN » Golgin subfamily A member 5
FUNCTION: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

SUBUNIT: Homodimer. Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1. Interacts with isoform CASP of CUX1.

TISSUE SPECIFICITY: Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa.

DISEASE: Thyroid papillary carcinoma (TPC) OMIM: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving GOLGA5 is found in thyroid papillary carcinomas. Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene which was found in 2 cases of PACT in children exposed to radioactive fallout after Chernobyl.

UniProt features for GOGA5_HUMAN » Golgin subfamily A member 5
CHAIN 1 731 Golgin subfamily A member 5.
COILED 216 632 Potential.
SITE 497 498 Breakpoint for translocation to form RET- GOLGA5 oncogene.
Amino Acid Sequence for GOGA5_HUMAN » Golgin subfamily A member 5
MSWFVDLAGK AEDLLNRVDQ GAATALSRKD NASNIYSKNT DYTELHQQNT DLIYQTGPKS TYISSAADNI RNQKATILAG TANVKVGSRT PVEASHPVEN ASVPRPSSHF VRRKKSEPDD ELLFDFLNSS QKEPTGRVEI RKEKGKTPVF QSSQTSSVSS VNPSVTTIKT IEENSFGSQT HEAASNSDSS HEGQEESSKE NVSSNAACPD HTPTPNDDGK SHELSNLRLE NQLLRNEVQS LNQEMASLLQ RSKETQEELN KARARVEKWN ADHSKSDRMT RGLRAQVDDL TEAVAAKDSQ LAVLKVRLQE ADQLLSTRTE ALEALQSEKS RIMQDQSEGN SLQNQALQTL QERLHEADAT LKREQESYKQ MQSEFAARLN KVEMERQNLA EAITLAERKY SDEKKRVDEL QQQVKLYKLN LESSKQELID YKQKATRILQ SKEKLINSLK EGSGFEGLDS STASSMELEE LRHEKEMQRE EIQKLMGQIH QLRSELQDME AQQVNEAESA REQLQDLHDQ IAGQKASKQE LETELERLKQ EFHYIEEDLY RTKNTLQSRI KDRDEEIQKL RNQLTNKTLS NSSQSELENR LHQLTETLIQ KQTMLESLST EKNSLVFQLE RLEQQMNSAS GSSSNGSSIN MSGIDNGEGT RLRNVPVLFN DTETNLAGMY GKVRKAASSI DQFSIRLGIF LRRYPIARVF VIIYMALLHL WVMIVLLTYT PEMHHDQPYG K