GNT2A_HUMAN » N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A

GNT2A_HUMAN » N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A
Magnify GNT2A_HUMAN » N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform AEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
GNT2A_HUMAN » N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A » N-acetylglucosaminyltransferase; I-branching enzyme;IGNT;
Hydrophobic Thickness 31.2 ± 5.2 Å
Tilt Angle 4 ± 12°
ΔGtransfer -18.2 kcal/mol
ΔGfold -11.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 8-28 (4-32)
Pathways

Glycosphingolipid biosynthesis - lacto and neolacto series (KEGG)

PDB none
OPM none
Complexes none
Interactions

GNT2B, Complex: GNT2A:GNT2B

Domains

AA: 97-358, PDBID: 2GAK, Subunit B, Seq Identity:41%, Core-2/I-Branching enzyme

UniProt annotation for GNT2A_HUMAN » N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A
FUNCTION: Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C.

CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + beta-D- galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D- glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.

TISSUE SPECIFICITY: Isoform B is expressed in lens epithelium cells. Isoform C is expressed in reticulocytes.

UniProt features for GNT2A_HUMAN » N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A
CHAIN 1 402 N-acetyllactosaminide beta-1,6-N- acetylglucosaminyl-transferase, isoform A.
Amino Acid Sequence for GNT2A_HUMAN » N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A
MMGSWKHCLF SASLISALIF VFVYNTELWE NKRFLRAALS NASLLAEACH QIFEGKVFYP TENALKTTLD EATCYEYMVR SHYVTETLSE EEAGFPLAYT VTIHKDFGTF ERLFRAIYMP QNVYCVHLDQ KATDAFKGAV KQLLSCFPNA FLASKKESVV YGGISRLQAD LNCLEDLVAS EVPWKYVINT CGQDFPLKTN REIVQYLKGF KGKNITPGVL PPDHAVGRTK YVHQELLNHK NSYVIKTTKL KTPPPHDMVI YFGTAYVALT RDFANFVLQD QLALDLLSWS KDTYSPDEHF WVTLNRIPGV PGSMPNASWT GNLRAIKWSD MEDRHGGCHG HYVHGICIYG NGDLKWLVNS PSLFANKFEL NTYPLTVECL ELRHRERTLN QSETAIQPSW YF