GLPC_HUMAN » Glycophorin-C

GLPC_HUMAN » Glycophorin-C
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
GLPC_HUMAN » Glycophorin-C » PAS-2';Glycoprotein beta;Glycoconnectin;Sialoglycoprotein D;Glycophorin-D;GPD;
Hydrophobic Thickness 36.0 ± 3.2 Å
Tilt Angle 41 ± 0°
ΔGtransfer -34.6 kcal/mol
ΔGfold -29.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 56-85 (54-87)
Pathways

Malaria (KEGG)

PDB 2ejy (B=117-126)
OPM none
Complexes none
Interactions none
Domains none
UniProt annotation for GLPC_HUMAN » Glycophorin-C
FUNCTION: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.

TISSUE SPECIFICITY: Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.

UniProt features for GLPC_HUMAN » Glycophorin-C
CHAIN 1 128 Glycophorin-C.
SITE 8 8 Not glycosylated; in variant Webb antigen.
Amino Acid Sequence for GLPC_HUMAN » Glycophorin-C
MWSTRSPNST AWPLSLEPDP GMASASTTMH TTTIAEPDPG MSGWPDGRME TSTPTIMDIV VIAGVIAAVA IVLVSLLFVM LRYMYRHKGT YHTNEAKGTE FAESADAALQ GDPALQDAGD SSRKEYFI