GLPA_HUMAN » Glycophorin-A

GLPA_HUMAN » Glycophorin-A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
GLPA_HUMAN » Glycophorin-A » MN sialoglycoprotein;PAS-2;Sialoglycoprotein alpha;
Hydrophobic Thickness 32.8 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -40.1 kcal/mol
ΔGfold -17.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 89-115 (89-121)
Pathways

Hematopoietic cell lineage (KEGG)

Malaria (KEGG)

PDB 2kpf (A/B=80-117), 1afo (A/B=81-120), 2kpe (A/B=89-117)
OPM 1afo
Complexes

GLPA:GLPA_HUMAN

Interactions

GLPA, Complex: Transmembrane homodimer of glycophorin A, PDBID: 1AFO

Domains

AA: 34-146, PDBID: 1AFO, Subunit B, Seq Identity:100%, Glycophorin A

UniProt annotation for GLPA_HUMAN » Glycophorin-A
FUNCTION: Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).

SUBUNIT: Homodimer. Interacts with Streptococcus gordonii hsa protein.

MISCELLANEOUS: Involved in several unequal homologous recombinations or gene conversion events, predominantly with GYPB and more rarely with GYPE. The resulting fusion proteins are observed in different phenotypes and encode low incidence bloodgroup antigens.

UniProt features for GLPA_HUMAN » Glycophorin-A
SIGNAL 1 19
CHAIN 20 150 Glycophorin-A.
Amino Acid Sequence for GLPA_HUMAN » Glycophorin-A
MYGKIIFVLL LSEIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNDTHKR DTYAATPRAH EVSEISVRTV YPPEEETGER VQLAHHFSEP EITLIIFGVM AGVIGTILLI SYGIRRLIKK SPSDVKPLPS PDTDVPLSSV EIENPETSDQ