GLDN_HUMAN » Gliomedin

GLDN_HUMAN » Gliomedin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
GLDN_HUMAN » Gliomedin »
Hydrophobic Thickness 34.2 ± 4.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -9.7 kcal/mol
ΔGfold -9.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 19-41 (19-42)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 136-193, PDBID: 1M7L, Subunit A, Seq Identity:41%, Collagen triple helix repeat (20 copies)

AA: 166-225, PDBID: 1M7L, Subunit A, Seq Identity:46%, Collagen triple helix repeat (20 copies)

AA: 304-544, PDBID: 4XAV, Subunit D, Seq Identity:90%, Olfactomedin-like domain

UniProt annotation for GLDN_HUMAN » Gliomedin
FUNCTION: Plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of the nodes of Ranvier (By similarity).

SUBUNIT: Interacts with NFASC/neurofascin, MYOC and NRCAM.

TISSUE SPECIFICITY: Specifically expressed in spinal cord, brain, placenta and sciatic nerve. More abundant in peripheral than central nervous system.

DOMAIN: The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding.

UniProt features for GLDN_HUMAN » Gliomedin
CHAIN 1 551 Gliomedin.
DOMAIN 137 195 Collagen-like 1.
DOMAIN 196 222 Collagen-like 2.
DOMAIN 299 546 Olfactomedin-like.
Amino Acid Sequence for GLDN_HUMAN » Gliomedin
MARGAEGGRG DAGWGLRGAL AAVALLSALN AAGTVFALCQ WRGLSSALRA LEAQRGREQR EDSALRSFLA ELSRAPRGAS APPQDPASSA RNKRSHSGEP APHIRAESHD MLMMMTYSMV PIRVMVDLCN STKGICLTGP SGPPGPPGAG GLPGHNGLDG QPGPQGPKGE KGANGKRGKM GIPGAAGNPG ERGEKGDHGE LGLQGNEGPP GQKGEKGDKG DVSNDVLLAG AKGDQGPPGP PGPPGPPGPP GPPGSRRAKG PRQPSMFNGQ CPGETCAIPN DDTLVGKADE KASEHHSPQA ESMITSIGNP VQVLKVTETF GTWIRESANK SDDRIWVTEH FSGIMVKEFK DQPSLLNGSY TFIHLPYYFH GCGHVVYNNS LYYHKGGSNT LVRFEFGQET SQTLKLENAL YFDRKYLFAN SKTYFNLAVD EKGLWIIYAS SVDGSSILVA QLDERTFSVV QHVNTTYPKS KAGNAFIARG ILYVTDTKDM RVTFAFDLLG GKQINANFDL RTSQSVLAML AYNMRDQHLY SWEDGHLMLY PVQFLSTTLN Q