GIMA5_HUMAN » GTPase IMAP family member 5

GIMA5_HUMAN » GTPase IMAP family member 5
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Topology in Lysosomal membrane
Topologylysosome lumenal side
cytoplasmic side
GIMA5_HUMAN » GTPase IMAP family member 5 » Immunity-associated nucleotide 4-like 1 protein;Immunity-associated nucleotide 5 protein;IAN-5; hIAN5; Immunity-associated protein 3;
Hydrophobic Thickness 33.6 ± 3.4 Å
Tilt Angle 18 ± 16°
ΔGtransfer -29.6 kcal/mol
ΔGfold -26.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 283-306 (283-306)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:GIMA5, PubMed

B2CL1, Complex: B2CL1:GIMA5

BAK, Complex: BAK:GIMA5

BAX, Complex: BAX:GIMA5

BCL2, Complex: BCL2:GIMA5

CC045, Complex: GIMA5:CC045

EDA, Complex: EDA:GIMA5

GRAM3, Complex: GIMA5:GRAM3

LRAD1, Complex: GIMA5:LRAD1

STX4, Complex: STX4:GIMA5

Domains

AA: 28-239, PDBID: 2XTM, Subunit B, Seq Identity:58%, AIG1 family

UniProt annotation for GIMA5_HUMAN » GTPase IMAP family member 5
FUNCTION: Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity).

TISSUE SPECIFICITY: Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T- cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms.

UniProt features for GIMA5_HUMAN » GTPase IMAP family member 5
CHAIN 1 307 GTPase IMAP family member 5.
Amino Acid Sequence for GIMA5_HUMAN » GTPase IMAP family member 5
MGGFQRGKYG TMAEGRSEDN LSATPPALRI ILVGKTGCGK SATGNSILGQ PVFESKLRAQ SVTRTCQVKT GTWNGRKVLV VDTPSIFESQ ADTQELYKNI GDCYLLSAPG PHVLLLVIQL GRFTAQDTVA IRKVKEVFGT GAMRHVVILF THKEDLGGQA LDDYVANTDN CSLKDLVREC ERRYCAFNNW GSVEEQRQQQ AELLAVIERL GREREGSFHS NDLFLDAQLL QRTGAGACQE DYRQYQAKVE WQVEKHKQEL RENESNWAYK ALLRVKHLML LHYEIFVFLL LCSILFFIIF LFIFHYI