![]() | Golgi lumenal side |
cytoplasmic side |
GIMA4_HUMAN » GTPase IMAP family member 4 » Immunity-associated nucleotide 1 protein;IAN-1; hIAN1; Immunity-associated protein 4; | |
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Hydrophobic Thickness | 34.6 ± 3.1 Å |
Tilt Angle | 1 ± 0° |
ΔGtransfer | -18.1 kcal/mol |
ΔGfold | -11.1 kcal/mol |
Links | UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB |
Topology | In |
TM Segments | 305-327 (300-328) |
Pathways | none |
PDB | 3lxx (A=20-240) |
OPM | none |
Complexes | none |
Interactions | |
Domains | AA: 31-241, PDBID: 3LXX, Subunit A, Seq Identity:100%, AIG1 family |
UniProt annotation for GIMA4_HUMAN » GTPase IMAP family member 4 |
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FUNCTION: May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium. TISSUE SPECIFICITY: Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine. |
UniProt features for GIMA4_HUMAN » GTPase IMAP family member 4 |
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CHAIN 1 329 GTPase IMAP family member 4. COILED 188 300 Potential. |
Amino Acid Sequence for GIMA4_HUMAN » GTPase IMAP family member 4 |
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MAAQYGSMSF NPSTPGASYG PGRQEPRNSQ LRIVLVGKTG AGKSATGNSI LGRKVFHSGT AAKSITKKCE KRSSSWKETE LVVVDTPGIF DTEVPNAETS KEIIRCILLT SPGPHALLLV VPLGRYTEEE HKATEKILKM FGERARSFMI LIFTRKDDLG DTNLHDYLRE APEDIQDLMD IFGDRYCALN NKATGAEQEA QRAQLLGLIQ RVVRENKEGC YTNRMYQRAE EEIQKQTQAM QELHRVELER EKARIREEYE EKIRKLEDKV EQEKRKKQME KKLAEQEAHY AVRQQRARTE VESKDGILEL IMTALQIASF ILLRLFAED |