GIMA4_HUMAN » GTPase IMAP family member 4

GIMA4_HUMAN » GTPase IMAP family member 4
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
GIMA4_HUMAN » GTPase IMAP family member 4 » Immunity-associated nucleotide 1 protein;IAN-1; hIAN1; Immunity-associated protein 4;
Hydrophobic Thickness 34.6 ± 3.1 Å
Tilt Angle 1 ± 0°
ΔGtransfer -18.1 kcal/mol
ΔGfold -11.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 305-327 (300-328)
Pathways none
PDB 3lxx (A=20-240)
OPM none
Complexes none
Interactions

A4, Complex: A4:GIMA4, PubMed

Domains

AA: 31-241, PDBID: 3LXX, Subunit A, Seq Identity:100%, AIG1 family

UniProt annotation for GIMA4_HUMAN » GTPase IMAP family member 4
FUNCTION: May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.

TISSUE SPECIFICITY: Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.

UniProt features for GIMA4_HUMAN » GTPase IMAP family member 4
CHAIN 1 329 GTPase IMAP family member 4.
COILED 188 300 Potential.
Amino Acid Sequence for GIMA4_HUMAN » GTPase IMAP family member 4
MAAQYGSMSF NPSTPGASYG PGRQEPRNSQ LRIVLVGKTG AGKSATGNSI LGRKVFHSGT AAKSITKKCE KRSSSWKETE LVVVDTPGIF DTEVPNAETS KEIIRCILLT SPGPHALLLV VPLGRYTEEE HKATEKILKM FGERARSFMI LIFTRKDDLG DTNLHDYLRE APEDIQDLMD IFGDRYCALN NKATGAEQEA QRAQLLGLIQ RVVRENKEGC YTNRMYQRAE EEIQKQTQAM QELHRVELER EKARIREEYE EKIRKLEDKV EQEKRKKQME KKLAEQEAHY AVRQQRARTE VESKDGILEL IMTALQIASF ILLRLFAED