GIMA1_HUMAN » GTPase IMAP family member 1

GIMA1_HUMAN » GTPase IMAP family member 1
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
GIMA1_HUMAN » GTPase IMAP family member 1 » Immunity-associated protein 1;hIMAP1;
Hydrophobic Thickness 27.6 ± 3.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -37.0 kcal/mol
ΔGfold -16.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 274-293 (271-301)
Pathways none
PDB 3v70 (25-253)
OPM none
Complexes none
Interactions none
Domains

AA: 28-238, PDBID: 3V70, Subunit B, Seq Identity:100%, AIG1 family

UniProt annotation for GIMA1_HUMAN » GTPase IMAP family member 1
FUNCTION: May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity).

TISSUE SPECIFICITY: Predominantly expressed in the spleen and to a lesser extent in the lymph nodes. Detected in T-cells.

UniProt features for GIMA1_HUMAN » GTPase IMAP family member 1
CHAIN 1 306 GTPase IMAP family member 1.
Amino Acid Sequence for GIMA1_HUMAN » GTPase IMAP family member 1
MGGRKMATDE ENVYGLEENA QSRQESTRRL ILVGRTGAGK SATGNSILGQ RRFFSRLGAT SVTRACTTGS RRWDKCHVEV VDTPDIFSSQ VSKTDPGCEE RGHCYLLSAP GPHALLLVTQ LGRFTAQDQQ AVRQVRDMFG EDVLKWMVIV FTRKEDLAGG SLHDYVSNTE NRALRELVAE CGGRVCAFDN RATGREQEAQ VEQLLGMVEG LVLEHKGAHY SNEVYELAQV LRWAGPEERL RRVAERVAAR VQRRPWGAWL SARLWKWLKS PRSWRLGLAL LLGGALLFWV LLHRRWSEAV AEVGPD