GAPT_HUMAN » Protein GAPT

GAPT_HUMAN » Protein GAPT
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
GAPT_HUMAN » Protein GAPT » Growth factor receptor-bound protein 2-binding adapter protein, transmembrane;
Hydrophobic Thickness 38.0 ± 2.0 Å
Tilt Angle 0 ± 3°
ΔGtransfer -33.4 kcal/mol
ΔGfold -16.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 9-34 (9-39)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 1-155, GRB2-binding adapter (GAPT)

UniProt annotation for GAPT_HUMAN » Protein GAPT
FUNCTION: Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity).

SUBUNIT: Interacts with GRB2.

TISSUE SPECIFICITY: Highly expressed in spleen and PBL, detected at lower levels in thymus, and undetectable in all other tissues tested. Also expressed in various B-cell lines, monocytic cell line THP-1 and NK-like cell line YT, but not in T-cell line Jurkat or HeLa cells.

UniProt features for GAPT_HUMAN » Protein GAPT
CHAIN 1 157 Protein GAPT.
Amino Acid Sequence for GAPT_HUMAN » Protein GAPT
MSKSCGNNLA AISVGISLLL LLVVCGIGCV WHWKHRVATR FTLPRFLQRR SSRRKVCTKT FLGPRIIGLR HEISVETQDH KSAVRGNNTH DNYENVEAGP PKAKGKTDKE LYENTGQSNF EEHIYGNETS SDYYNFQKPR PSEVPQDEDI YILPDSY