FTSQ_ECOLI » Cell division protein FtsQ

FTSQ_ECOLI » Cell division protein FtsQ
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Topology in Bacterial Gram-negative inner membrane
Topologyextracellular side
cytoplasmic side
FTSQ_ECOLI » Cell division protein FtsQ »
Hydrophobic Thickness 32.4 ± 5.8 Å
Tilt Angle 31 ± 4°
ΔGtransfer -24.2 kcal/mol
ΔGfold -17.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 21-46 (21-54)
Pathways

Cell cycle - Caulobacter (KEGG)

PDB 4v6m (22-103), 2vh1 (58-276)
OPM none
Complexes none
Interactions

BLR, Complex: FTSQ:BLR, PubMed

DAMX, Complex: FTSQ:DAMX, PubMed

FTSB, Complex: FTSQ:FTSB, PubMed

FTSI, Complex: FTSI:FTSQ

FTSL, Complex: FTSL:FTSQ

FTSN, Complex: FTSN:FTSQ

Domains

AA: 55-126, PDBID: 2VH1, Subunit B, Seq Identity:100%, POTRA domain, FtsQ-type

AA: 130-247, PDBID: 2VH1, Subunit B, Seq Identity:100%, Cell division protein FtsQ

UniProt annotation for FTSQ_ECOLI » Cell division protein FtsQ
FUNCTION: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.

SUBUNIT: Part of a complex composed of FtsB, FtsL and FtsQ. The complex can be formed before its localization to the division site. This tripartite complex can be divided further into a subcomplex of FtsB and FtsL, which forms in the absence of FtsQ. Interacts with FtsA, FtsK, FtsL, FtsB, FtsW, FtsI, FtsN, FtsX and YmgF.

DOMAIN: The C-terminal periplasmic region is necessary and sufficient for septal targeting. The transmembrane region contributes to localization to the cell division site. Three periplasmic subdomains are involved in the interactions with other cell division proteins. Localization and recruitment require two separate domains.

UniProt features for FTSQ_ECOLI » Cell division protein FtsQ
CHAIN 1 276 Cell division protein FtsQ.
Amino Acid Sequence for FTSQ_ECOLI » Cell division protein FtsQ
MSQAALNTRN SEEEVSSRRN NGTRLAGILF LLTVLTTVLV SGWVVLGWME DAQRLPLSKL VLTGERHYTR NDDIRQSILA LGEPGTFMTQ DVNIIQTQIE QRLPWIKQVS VRKQWPDELK IHLVEYVPIA RWNDQHMVDA EGNTFSVPPE RTSKQVLPML YGPEGSANEV LQGYREMGQM LAKDRFTLKE AAMTARRSWQ LTLNNDIKLN LGRGDTMKRL ARFVELYPVL QQQAQTDGKR ISYVDLRYDS GAAVGWAPLP PEESTQQQNQ AQAEQQ