FTSH2_ARATH » ATP-dependent zinc metalloprotease FTSH 2, chloroplastic

FTSH2_ARATH » ATP-dependent zinc metalloprotease FTSH 2, chloroplastic
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Topology in Thylakoid membrane
Topologythylakoid lumen
chloroplast stroma
FTSH2_ARATH » ATP-dependent zinc metalloprotease FTSH 2, chloroplastic » AtFTSH2; Protein VARIEGATED 2;
Hydrophobic Thickness 31.2 ± 3.6 Å
Tilt Angle 15 ± 7°
ΔGtransfer -19.0 kcal/mol
ΔGfold -9.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 169-190 (163-193)
Pathways none
PDB none
OPM none
Complexes none
Interactions

FTSH5, Complex: FTSH2:FTSH5, PubMed

Domains

AA: 263-396, PDBID: 1LV7, Subunit A, Seq Identity:82%, ATPase family associated with various cellular activities (AAA)

AA: 456-665, PDBID: 1LV7, Subunit A, Seq Identity:42%, Peptidase family M41

UniProt annotation for FTSH2_ARATH » ATP-dependent zinc metalloprotease FTSH 2, chloroplastic
FUNCTION: Part of a complex that function as an ATP-dependent zinc metallopeptidase. Involved in the thylakoid formation and in the removal of damaged D1 in the photosystem II, preventing cell death under high-intensity light conditions, but not involved in thermotolerance.

SUBUNIT: Interacts with CHIP and FTSH5. Heterohexamers with FTSH1, FTSH5 and FTSH8. May also form homooligomers.

TISSUE SPECIFICITY: Expressed in cotyledons, cauline and rosette leaves, stems, sepals, flovers and siliques. Very low in roots.

DEVELOPMENTAL STAGE: Low expression in cotyledons, increasing with leaves development.

INDUCTION: By cold and high light.

DOMAIN: The conserved lumenal (CL) domain (83-161) is present only in some FtsH homologs from organisms performing oxygenic photosynthesis.

UniProt features for FTSH2_ARATH » ATP-dependent zinc metalloprotease FTSH 2, chloroplastic
TRANSIT 1 47 Chloroplast (Potential).
TRANSIT 48 82 Thylakoid (Probable).
CHAIN 83 695 ATP-dependent zinc metalloprotease FTSH 2, chloroplastic.
ACT_SITE 489 489 By similarity.
Amino Acid Sequence for FTSH2_ARATH » ATP-dependent zinc metalloprotease FTSH 2, chloroplastic
MAASSACLVG NGLSVNTTTK QRLSKHFSGR QTSFSSVIRT SKVNVVKASL DGKKKQEGRR DFLKILLGNA GVGLVASGKA NADEQGVSSS RMSYSRFLEY LDKDRVNKVD LYENGTIAIV EAVSPELGNR VERVRVQLPG LSQELLQKLR AKNIDFAAHN AQEDQGSVLF NLIGNLAFPA LLIGGLFLLS RRSGGGMGGP GGPGNPLQFG QSKAKFQMEP NTGVTFDDVA GVDEAKQDFM EVVEFLKKPE RFTAVGAKIP KGVLLIGPPG TGKTLLAKAI AGEAGVPFFS ISGSEFVEMF VGVGASRVRD LFKKAKENAP CIVFVDEIDA VGRQRGTGIG GGNDEREQTL NQLLTEMDGF EGNTGVIVVA ATNRADILDS ALLRPGRFDR QVSVDVPDVK GRTDILKVHA GNKKFDNDVS LEIIAMRTPG FSGADLANLL NEAAILAGRR ARTSISSKEI DDSIDRIVAG MEGTVMTDGK SKSLVAYHEV GHAVCGTLTP GHDAVQKVTL IPRGQARGLT WFIPSDDPTL ISKQQLFARI VGGLGGRAAE EIIFGDSEVT TGAVGDLQQI TGLARQMVTT FGMSDIGPWS LMDSSAQSDV IMRMMARNSM SEKLAEDIDS AVKKLSDSAY EIALSHIKNN REAMDKLVEV LLEKETIGGD EFRAILSEFT EIPPENRVPS STTTTPASAP TPAAV