FTSH1_ARATH » ATP-dependent zinc metalloprotease FTSH 1, chloroplastic

FTSH1_ARATH » ATP-dependent zinc metalloprotease FTSH 1, chloroplastic
Magnify FTSH1_ARATH » ATP-dependent zinc metalloprotease FTSH 1, chloroplasticEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Thylakoid membrane
Topologythylakoid lumen
chloroplast stroma
FTSH1_ARATH » ATP-dependent zinc metalloprotease FTSH 1, chloroplastic » AtFTSH1;
Hydrophobic Thickness 34.0 ± 3.8 Å
Tilt Angle 15 ± 8°
ΔGtransfer -24.4 kcal/mol
ΔGfold -12.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 203-227 (202-228)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 298-431, PDBID: 2CE7, Subunit D, Seq Identity:77%, ATPase family associated with various cellular activities (AAA)

AA: 491-705, PDBID: 1LV7, Subunit A, Seq Identity:45%, Peptidase family M41

UniProt annotation for FTSH1_ARATH » ATP-dependent zinc metalloprotease FTSH 1, chloroplastic
FUNCTION: Part of a complex that function as an ATP-dependent zinc metallopeptidase. Involved in the thylakoid formation and in the removal of damaged D1 in the photosystem II, preventing cell death under high-intensity light conditions.

SUBUNIT: Interacts with CHIP and HSP70. Heterohexamers with FTSH2, FTSH5 and FTSH8.

TISSUE SPECIFICITY: Ubiquitous.

DEVELOPMENTAL STAGE: Low expression in cotyledons, increasing with leaves development.

INDUCTION: By high light.

UniProt features for FTSH1_ARATH » ATP-dependent zinc metalloprotease FTSH 1, chloroplastic
TRANSIT 1 48 Chloroplast (Potential).
TRANSIT 49 86 Thylakoid (Probable).
CHAIN 87 716 ATP-dependent zinc metalloprotease FTSH 1, chloroplastic.
ACT_SITE 525 525 By similarity.
Amino Acid Sequence for FTSH1_ARATH » ATP-dependent zinc metalloprotease FTSH 1, chloroplastic
MASNSLLRSS SNFFLGSHII ISSPTPKTTR KPSFPFSFVS RAKYQITRSS QDENSPNGKP NSPFSSQVAL AAILLSSISS SPLALAVVDE PASPSVVIES QAVKPSTPSP LFIQNEILKA PSPKSSDLPE GSQWRYSEFL NAVKKGKVER VRFSKDGSVV QLTAVDNRRA SVIVPNDPDL IDILAMNGVD ISVSEGESSG NDLFTVIGNL IFPLLAFGGL FLLFRRAQGG PGGGPGGLGG PMDFGRSKSK FQEVPETGVS FADVAGADQA KLELQEVVDF LKNPDKYTAL GAKIPKGCLL VGPPGTGKTL LARAVAGEAG VPFFSCAASE FVELFVGVGA SRVRDLFEKA KSKAPCIVFI DEIDAVGRQR GAGMGGGNDE REQTINQLLT EMDGFSGNSG VIVLAATNRP DVLDSALLRP GRFDRQVTVD RPDVAGRVKI LQVHSRGKAL GKDVDFDKVA RRTPGFTGAD LQNLMNEAAI LAARRELKEI SKDEISDALE RIIAGPEKKN AVVSEEKKRL VAYHEAGHAL VGALMPEYDP VAKISIIPRG QAGGLTFFAP SEERLESGLY SRSYLENQMA VALGGRVAEE VIFGDENVTT GASNDFMQVS RVARQMIERF GFSKKIGQVA VGGPGGNPFM GQQMSSQKDY SMATADIVDA EVRELVEKAY KRATEIITTH IDILHKLAQL LIEKETVDGE EFMSLFIDGQ AELYIS