FTSB_ECOLI » Cell division protein FtsB

FTSB_ECOLI » Cell division protein FtsB
Magnify FTSB_ECOLI » Cell division protein FtsBEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Bacterial Gram-negative inner membrane
Topologyextracellular side
cytoplasmic side
FTSB_ECOLI » Cell division protein FtsB »
Hydrophobic Thickness 26.8 ± 3.8 Å
Tilt Angle 1 ± 0°
ΔGtransfer -29.6 kcal/mol
ΔGfold -10.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 3-19 (3-24)
Pathways none
PDB 4iff (A/B/C/D=28-63)
OPM none
Complexes none
Interactions

FTSI, Complex: FTSB:FTSI, PubMed

FTSL, Complex: FTSB:FTSL, PubMed

FTSN, Complex: FTSB:FTSN, PubMed

FTSQ, Complex: FTSQ:FTSB, PubMed

Domains

AA: 11-90, PDBID: 4IFF, Subunit C, Seq Identity:100%, Septum formation initiator

UniProt annotation for FTSB_ECOLI » Cell division protein FtsB
FUNCTION: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.

SUBUNIT: Part of a complex composed of FtsB, FtsL and FtsQ. The complex can be formed before its localization to the division site. This tripartite complex can be divided further into a subcomplex of FtsB and FtsL, which forms in the absence of FtsQ. Interacts also with FtsI and FtsN.

DOMAIN: The transmembrane segment and the membrane-proximal periplasmic region, which forms a coiled-coil structure, are required for interaction with FtsL and recruitment of downstream division proteins. The C-terminal region is required for interaction with FtsQ, but is not required for recruitment of the downstream division protein FtsI. Contains a leucine zipper-like (LZ) motif, which is required for optimal interaction with FtsL.

MISCELLANEOUS: The C-terminal domain of FtsB is degraded in the absence of either FtsL or FtsQ.

UniProt features for FTSB_ECOLI » Cell division protein FtsB
CHAIN 1 103 Cell division protein FtsB.
COILED 31 71 Potential.
MOTIF 41 72 Leucine zipper-like.
Amino Acid Sequence for FTSB_ECOLI » Cell division protein FtsB
MGKLTLLLLA ILVWLQYSLW FGKNGIHDYT RVNDDVAAQQ ATNAKLKARN DQLFAEIDDL NGGQEALEER ARNELSMTRP GETFYRLVPD ASKRAQSAGQ NNR