FRMD3_HUMAN » FERM domain-containing protein 3

FRMD3_HUMAN » FERM domain-containing protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
FRMD3_HUMAN » FERM domain-containing protein 3 » Band 4.1-like protein 4O;Ovary type protein 4.1;4.1O;
Hydrophobic Thickness 34.4 ± 2.4 Å
Tilt Angle 9 ± 7°
ΔGtransfer -28.1 kcal/mol
ΔGfold -17.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 527-551 (527-552)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 36-99, PDBID: 2HE7, Subunit A, Seq Identity:48%, FERM N-terminal domain

AA: 115-225, PDBID: 2HE7, Subunit A, Seq Identity:55%, FERM central domain

AA: 229-316, PDBID: 2HE7, Subunit A, Seq Identity:28%, FERM C-terminal PH-like domain

AA: 323-366, FERM adjacent (FA)

UniProt annotation for FRMD3_HUMAN » FERM domain-containing protein 3
FUNCTION: Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.

TISSUE SPECIFICITY: Ovary-specific.

DEVELOPMENTAL STAGE: Expressed in skeletal muscle, lower levels in thymus and brain.

UniProt features for FRMD3_HUMAN » FERM domain-containing protein 3
CHAIN 1 597 FERM domain-containing protein 3.
DOMAIN 32 312 FERM.
Amino Acid Sequence for FRMD3_HUMAN » FERM domain-containing protein 3
MFASCHCVPR GRRTMKMIHF RSSSVKSLSQ EMRCTIRLLD DSEISCHIQR ETKGQFLIDH ICNYYSLLEK DYFGIRYVDP EKQRHWLEPN KSIFKQMKTH PPYTMCFRVK FYPHEPLKIK EELTRYLLYL QIKRDIFHGR LLCSFSDAAY LGACIVQAEL GDYDPDEHPE NYISEFEIFP KQSQKLERKI VEIHKNELRG QSPPVAEFNL LLKAHTLETY GVDPHPCKDS TGTTTFLGFT AAGFVVFQGN KRIHLIKWPD VCKLKFEGKT FYVIGTQKEK KAMLAFHTST PAACKHLWKC GVENQAFYKY AKSSQIKTVS SSKIFFKGSR FRYSGKVAKE VVEASSKIQR EPPEVHRANI TQSRSSHSLN KQLIINMEPL QPLLPSPSEQ EEELPLGEGV PLPKEENISA PLISSSPVKA AREYEDPPSE EEDKIKEEPL TISELVYNPS ASLLPTPVDD DEIDMLFDCP SRLELEREDT DSFEDLEADE NAFLIAEEEE LKEARRALSW SYDILTGHIR VNPLVKSFSR LLVVGLGLLL FVFPLLLLLL ESGIDLSFLC EIRQTPEFEQ FHYEYYCPLK EWVAGKVHLI LYMLGCS