FR1L5_HUMAN » Fer-1-like protein 5

FR1L5_HUMAN » Fer-1-like protein 5
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
FR1L5_HUMAN » Fer-1-like protein 5 »
Hydrophobic Thickness 32.4 ± 3.8 Å
Tilt Angle 22 ± 19°
ΔGtransfer -27.3 kcal/mol
ΔGfold -21.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 1994-2017 (1989-2018)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 1-99, PDBID: 2DMH, Subunit A, Seq Identity:33%, C2 domain

AA: 167-229, PDBID: 3NSJ, Subunit A, Seq Identity:28%, C2 domain

AA: 308-410, PDBID: 2EP6, Subunit A, Seq Identity:29%, C2 domain

AA: 599-665, FerA (NUC095) domain

AA: 687-760, FerB (NUC096) domain

AA: 1103-1197, PDBID: 1DQV, Subunit A, Seq Identity:24%, C2 domain

AA: 1271-1373, PDBID: 3NSJ, Subunit A, Seq Identity:26%, C2 domain

AA: 1513-1613, PDBID: 1DQV, Subunit A, Seq Identity:34%, C2 domain

AA: 1758-1890, PDBID: 3L9B, Subunit A, Seq Identity:16%, C2 domain

AA: 1923-2025, Ferlin C-terminus

UniProt annotation for FR1L5_HUMAN » Fer-1-like protein 5
FUNCTION: Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.

SUBUNIT: Interacts (via second C2 domain) with EHD1 and EHD2.

UniProt features for FR1L5_HUMAN » Fer-1-like protein 5
CHAIN 1 2093 Fer-1-like protein 5.
DOMAIN 1 83 C2 1.
DOMAIN 154 292 C2 2.
DOMAIN 295 391 C2 3.
DOMAIN 1090 1195 C2 4.
DOMAIN 1500 1598 C2 5.
DOMAIN 1744 1872 C2 6.
Amino Acid Sequence for FR1L5_HUMAN » Fer-1-like protein 5
MLRLVVQSAK IDPPLAPLPR PCMSIDFRDI KKRTRVVEGN DPVWNETLIW HLWNRPLEND SFLQVTLQDM GSQKKERFIG LATVLLKPLL KQPSEVLFVK DLTLLNHSMK PTDCTVTLQV AHMSNQDIEK TGAEDHLGIT AREAASQKLM VPGSTAHRAL SSKPQHFQVR VKVFEARQLM GNNIKPVVKV SIAGQQHQTR IKMGNNPFFN EIFFQNFHEV PAKFFDETIL IQTDIGFIYH SPGHTLLRKW LGLCQPNNPG SGVTGYLKVT IYALGVGDQA LIDQKLLYGT DDTDIQIFKS AVVPINMAYL QLFIYCAEDL HLKKHQSVNP QLEVELIGEK LRTHMQTQTD NPIWNQILTF RIQLPCLSSY IKFRVLDCRK KDCPDEIGTA SLSLNQISST GEEIEGKQSL EPTSYTPRVY SGFLPCFGPS FLTLHGGKKA PFRIQEEGAC IPDSVRDGLA YRGRVFLELI TQIKSYQDST IKDLSHEVTR IEKHQNRQKY GLCVIFLSCT MMPNFKELIH FEVSIGHYGN KMDLNYKPLV SSTPYSPVIY DGNIYHYVPW YNTKPVVAVT SNWEDVSFRM NCLNLLHFTR DRLKANLDTL KSTRNPKDPA LLYQWEKLLR ELAEDCKRPL PCMTYQPKAT SLDRKRWQLR SLLLQELAQK AKQAKPKDMV ATAEDWLYRL NTVLPEPQMG LPDVMIWLVA KEQRVAYAQV PAHSVLFSPA GALHSGRLCG KIQTLFLQYP EGEGQKDVLP AHLRVCMWLG NVTDSKDLQL LRQGDTAVYA EMYENQAKYK DQWGQQGLYH CPNFSDVMGN KTLPMTDFQP PLGWHWQDSW TVEPQRRLLL DIDINKSQVL EEVYENQGRD TRGAWGPAAI PNTDVNGQPM EARENVKCPQ GWHFKKDWVV ELNHAVDSWE YGVGIPPSGL PQVWSPVEKT YHSCRRRRWA RVRFRNHGEL SHEQETLSFL QLGLAKGEEE GWEYDTFGSK FHLNPQPQSR FRRRCWRRRL APNKDKGIAP IFLLEGSLAC EGGSVREEGD WAWARGNRSS TQEPQGRLSW VQAMDLKYHA GKEEDSKTWP WGLDRQFRDP QRQDTRPPNL PFIYCTFNKP HYYQLFCYIY QARNLVSNQI LTFQGPFIRV VFLNHSQCTQ TLRSSAGPTW AQTLIFQHLL LYENPQDTKE SPPLVVLELW QRDFWGKESL WGRSVWPPMV WLDLQDRILP PMRWHPLVKE LGKEEGEILA SCELILQTEK LGEKQLPILS VPWKNGAYTL PKSIQPTIKR MAIEILAWGL RNMKKASSPQ LLVEFGEESL RTEPIRDFQT NPNFPESESV LVLTVLMPTE EAYALPLVVK VVDNWAFGQQ TVTGQANIDF LQPYFCDPWA QDYMHPKLPT LSEKKHQDFL GYLYRKFWFK SSKAEDEYEH EVDWWSKLFW ATDEHKSLKY KYKDYHTLKV YECELEAVPA FQGLQDFCQT FKLYQEQPKL DSPVVGEFKG LFRIYPFPEN PEAPKPPLQF LVWPEREDFP QPCLVRVYMV RAINLQPQDY NGLCDPYVIL KLGKTELGNR DMYQPNTLDP IFGMMFELTC NIPLEKDLEI QLYDFDLFSP DDKIGTTVID LENRLLSGFG AHCGLSKSYC QSGPFRWRDQ MPPSYLLERY AKRKGLPPPL FSPEEDAVFY NGKKFKLQSF EPKTPTVHGL GPKKERLALY LLHTQGLVPE HVETRTLYSH SQPGIDQGKV QMWVDIFPKK LGPPGPQVNI NPRKPKRKAS EHSGHRYELR CIIWKTANVD LVDDNLSREK TSDIYIKGWL YGLEKDMQKT DIHYHSLTGE ADFNWRFIFT MDYLAAERTC VQSQKDYIWS LDATSMKFPA RLIIQVWDND IFSPDDFLGV LELDLSDMPL PARHAKQCSI RMMDADPKWP YFIQYKHFSL FKKKTVTGWW PCQVLDGGKW RLSGKVKMSL EILSEKEALI KPAGRGQSEP NQYPTLHPPL RTNTSFTWLR SPVQNFCYIF WKRYRFKLIA FMVISIIALM LFNFIYSAPH YLAMSWIKPQ LQLYPPIKIF NIINSLNTSN ASSSILPTQD PNLKPTIDHE WKLHPGPTNH LSDIFPELPA PGD